Antidepressants 2 Flashcards
(21 cards)
Which two drug classes when given together cause Central Serotonin Syndrome? and what it is that syndrome?
MAOI +SSRI
fever, convulsions, death
What amine potentiates MAOIs and causes hypertensive crisis
tyramine
Tyramine is found in what foods
beer, cheese, wine, coffee, yeast, canned figs
MAOIs interfere with the metabolic degradation of what types of drugs
anesthesias, sedatives, analgesics, alcohol, anticholinergics, tricyclics, antihistamines
What three drugs are used to treat bipolar disorder
Lithium
Divalproex
Carbamazepine
Lithium needs to be given at ____concentration
high
Lithium has a HI/LOW therapeutic index?
LOW
What two anticonvulsants can be given to treat bipolar disorder
sodium valproate
Carbamazepine
Which antidepressants are the most cardiotoxic
tricyclics:
Imipramine and amitryptiline
tricyclics block what receptors
NE, 5HT, muscarinic, histamine, A2, A1
What are the side effects of tricyclics
dry mouth, constipation, decreased sweating, sedation, hypotension
Tricyclics are contraindicated in bipolar disorder TRUE/FALSE
TRUE; they cause mania
Which two drugs do not cause sexual dysfunction as a side effect
Buproprion and Mirtazapine
Which drug is used in smoking cessation
Buproprion
What are the side effects of Venlafaxine and Mirtazapine
Nausea, vomitting, headache, sexual dysfunciton
Which heterocyclic is also used as an anxiolytic
Mirtazapine
SSRI’s mechanism
selectively target serotonins receptors only and block the reuptake of serotonin 5HT
What are the side effects of SSRIs
nausea, vomitting, headache, sexual dysfunction
inhibit P450s: increases the plasma levels of other drugs**
Which SSRI has the longest half life
Fluoxetine
What are the SSRIs
Fluoxetine
Paroxetine
Setraline
When giving lithium should a low NA diet be maintained
NOOOOO; HIGH salt diet
