Antidepressants

Question 1

isoniazid, phenelzine, tranylcypromine

Answer 1

MAOI (irreversible)

Question 2

mocolobemide

Answer 2

MAOI (reverisble)

Question 3

MAO A

Answer 3

5HT

Question 4

MAO B

Answer 4

DA/NA

Question 5

MAOI side effects (5)

Answer 5

M1,H1,alpha1,5HT2, cheese reaction

Question 6

drug interactions with MAOI

Answer 6

amphetamine
alcohol
pethidine (opioid)
anaesthetics

Question 7

amitryptiline

Answer 7

NA/5HT TCA

Question 8

desipramine

Answer 8

NA TCA

Question 9

clomipramine

Answer 9

5HT TCA

Question 10

TCA side effects (5)

Answer 10

H1,M1,5HT2,alpha1, cardiotoxicity

Question 11

fluoxetine, paroxetine, citalopram

Answer 11

ssri

Question 12

reboxetine

Answer 12

snri

Question 13

fluoxetine side effects

Answer 13

5HT

Question 14

reboxetine side effects

Answer 14

M and NA

Question 15

sertraline

Answer 15

ssri - best acceptability and efficacy

Question 16

discontinuation syndrome common in…

Answer 16

peroxetine

Question 17

venlafaxine

Answer 17

atypical - snri and 5ht antag for non responders/ extreme, weight gaining, retarded, hypersomniac

Question 18

trazedone

Answer 18

atypical - ssri and 5ht2 antag

Question 19

mirtazapine

Answer 19

na and 5ht antag, inc na autoreceptors

Question 20

agomelatine

Answer 20

atypical - melatonin agonist and 5ht2 antag

Question 21

ketamine

Answer 21

NMDA antag for treatment resistant patients (1x per week, with typical)

Question 22

lithium

Answer 22

mood stabiliser

reduce glut (replace na+)
gene expression
2nd messangers

Question 23

lithium side effects(7)

Answer 23

teratogenic, arrythmias, nausea, hypothyroid, tremor, dysarthria, ataxia

Question 24

valproate, carbemazepine

Answer 24

anticonvulsants (+mood stabiliser)

Question 25

haloperidol (acute), olanzapine (longterm)

Answer 25

antipsychotics as mood stabilisers

Question 26

valproate side effects (6)

Answer 26

``` inc liver transaminase nausea diarrhoea ataxia dysarthria weight gain ```

Question 27

carbemazepine side effects (5)

Answer 27

``` dizziness sedation ataxia leukopenia rash ```

Question 28

lithium action - bipolar

Answer 28

block ipp and impase

Question 29

vpa action - bipolar

Answer 29

block gluc-6-p --> IP1 via ino-1

Question 30

post synaptic agonist

Answer 30

busiprone

Question 31

nefazedone

Answer 31

snri/ssri and 5ht2 antag