Antidepressants & ECT I Flashcards Preview

Term IV: Behavioral Science > Antidepressants & ECT I > Flashcards

Flashcards in Antidepressants & ECT I Deck (25):
1

Decreased levels of what are found in patients who are prone to impulsive, violent suicidal acts?

CSF 5 HIAA

2

What chromosome is serotonin transporter gene (SERT) found on?

Chromosome 17

3

What functional polymorphism is found in promoter region of SERT gene? What condition results from people with the ss genotype?

44 base pair insertion (long - l) or deletion (short -s)

Depression or suicidal depression

4

Depletion of what amino acid can transiently reverse antidepressant response and cause short lived return of depressive symptoms?

Tryptophan

5

What part of the brain is densely innervated by both noradrenergic and dopamine systems?

Prefrontal cortex

6

What neurotransmitter is involved in process of working memory to regulate behavior and attention?

Norepinephrine

7

What neurotransmitter is involved in acquisition of emotionally arousing memories?

Norepinephrine

8

What neurotransmitter modulates amygdala in such a way as to strengthen memory consolidation and fear conditioning?

Norepinephrine

9

What types of dopamine receptors are more likely to be found in limbic areas?

D3 and D4

10

What types of dopamine receptors are found more widely in brain and are predominant subtype in striatum?

D1 and D2

11

Related to motor function

Nigrostriatal

12

Related to reward and motivation

Mesolimbic

13

Related to memory and attention

Mesoortical

14

Related to reinforcing properties of variety of drugs of abuse and pleasurable activities

Mesolimbic to nucleus accumbens

15

What neurotransmitter has a role in promoting interest and motivation?

Dopamine

16

Rapid, but transient improvement in mood has been reported in some depressed patients after acute administration of a _____

amphetamine

17

Patients with a major depressive disorder have what conditions within their hypothalamic pituitary adrenal axis?

hypercortisolemia, adrenal gland hypertrophy

18

What effects on hypothalamic pituitary axis can cause depression?

Hypothyroidism and hyperthyroidism because they can induce change in receptor density in particular brain regions

19

What hormone directly influences neuronal excitability and cholinergic, noradrenergic, and dopaminergic neurotransmission

TRH

20

What anatomical pathologies are seen in cerebral cortex?

Reductions in neuronal density and size of some populations of neurons

21

Depression is LARGELY associated with atrophy of what part of the brain?

Hippocampus

22

What is one neurotropin upregulated by antidepressants?

BDNF - brain derived neurotropic factor

23

What three neurotransmitters are increased by anti-depressants?

Dopamine, serotonin, norepinephrine

24

What is the time frame for clinical effectiveness for antidepressants? Why does it take this long?

Two-three weeks

Changes in gene regulation

25

Antidepressants are associated with inhibiting cytochrome P450 enzymes in what systems?

2D6 (hydrolyzes hydrocodone into active form), 3A3, and 3A4