Delirium/Dementia Flashcards

1
Q

Delirium is associated with:

A. Decreased mortality
B. A gradual onset
C. Alteration in level of consciousness/attention
D. Rapid improvement in underlying medical condition

A

C

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2
Q

Delirium is a disturbance in ____ and _____

A

Attention and awareness

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3
Q

T or F: Delirium develops over a long period of time.

A

FALSE - short period of time and fluctuates

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4
Q

3 delirium subtypes:

A

Hypoactive
Hyperactive
Mixed

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5
Q

Neuropathogenesis of delirium (list 3)

A
  • Impairment of cholinergic system
  • Excess dopamine
  • Increased GABA activity
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6
Q

Which of the following is NOT associated with an increased likelihood of delirium?

A. Infections
B. Alcohol withdrawal
C. PTSD
D. Stroke

A

C

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7
Q

Critical and emergent causes of delirium

A

Infection, withdrawal, acute metabolic, hypoxia, trauma, endocrinopathies, deficiencies, acute vascular accident, toxins/drugs/heavy metals

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8
Q

Can delirium lead to death?

A

YES

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9
Q

Predisposing factors for delirium

A

Older age, depression, stroke or TBI, alcohol abuse, male sex, dehydration, dementia

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10
Q

Precipitating factors for delirium

A

Anticholinergic meds ,UTI hyponatremia, hypoxemia, bladder catheter, ortho/cardiac surgery, narcotics, ICU admission, physical restraint

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11
Q

What labs should you run to determine underlying cause of delirium?

A

Electrolytes, BUN/Cr, LFTs, CBC, thyroid, urinalysis and toxicology, medication blood levels, EKG, CXR, CT

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12
Q

What medications can you prescribe for delirium?

A

Haloperidol, atypical antipsychotics (Risperidone, Olanzapine, Quetiapine), Lorazepam for alcohol detox

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13
Q

What behavioral treatments can you use to treat delirium?

A

AVOID RESTRAINTS, orienting devices (clocks, calendars, family pics), well-lit room, calm quiet env, frequent re-orientation

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14
Q

Dementia is cognitive decline in one or more cognitive domains that interferes w/ everyday activities:

(name the domains)

A
  1. Complex attention - sustained attn, processing speed
  2. Executive function - planning, decision making, error correction
  3. Learning & Memory
  4. Language
  5. Perceptual-motor - visual perception, praxis, gnosis
  6. Social cognition - recognition of emotions, theory of mind
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15
Q

Three most common dementia subtypes:

A
#1 - Alzheimer's
Tied for #2 - Lewy Body, Vascular

Others: prion disease, alcohol abuse, TBI

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16
Q

Neuropathology of Alzheimer’s

A

Plaques (collections of AB protein)

Tangles (hyperphosphorylated tau protein)

17
Q

Neuropathology of Lewy Body dementia

A

Lewy bodies

18
Q

Neuropathology of vascular dementia

A

Chronic microvascular disease, large vascular events

19
Q
  • Donepezil (Aricept)
  • Galantamine (Razadyne)
  • Rivastigmine (Exelon)
A

Acetylcholinesterase inhibitors

Treat dementia

20
Q

Memantine (Namenda)

A

NMDA antagonist

Treats dementia

21
Q

What additional neuropsychiatric symptom can be seen with Alzheimer’s dementia?

A

Delusions, depression, anxiety, hallucinations

22
Q

What brain lobe can contribute to behavioral disturbances in dementia patients?

A

Frontal lobe

23
Q

Which of the following meds has a black box warning regarding increased mortality in the elderly?

A. Antipsychotics
B. Antidepressants
C. Anticonvulsants
D. Cholinesterase inhibitors

A

A

24
Q

Pharmacological treatment for behavioral symptoms of dementia

A

Acetaminophen
Acetylcholinesterase inhibitors
Trazodone, SSRI

Anticonvulsants and antipsychotics avoided

25
Q

Delirium or dementia?

Acute/subacute

A

Delirium

Dementia has insidious onset

26
Q

Delirium or dementia?

Chronic, progressive

A

Dementia

Delirium is transient, reversible

27
Q

Delirium or dementia?

Non-fluctuating

A

Dementia

Delirium is fluctuating

28
Q

Delirium or dementia?

Disorientation

A

Delirium

Dementia - sensorium usually clear