Antidepressants - Essential Drugs for Exam 1

Question 1

Maprotiline (Ludiomil)

Answer 1

Epileptogenic

Question 2

Amoxapine (Ascendin)

Answer 2

• Better than TCAs for relieving anxiety/behavioral agitation
• Blocks DA receptions - may induce Parkinsonian-like EPS

Question 3

Trazodone (Desyrel)

Answer 3

Heavy sedative effects; mainly used as a hypnotic

Question 4

Clomipramine (Anafranil)

Answer 4

Used to treat anxiety, pain, depression, OCD + panic disorders

Question 5

Fluoxetine (Prozac)

Answer 5

First released SSRI

Question 6

Sertraline (Zoloft)

Answer 6

Higher risk of serotonin syndrome + withdrawal syndromes

Question 7

Paroxetine (Paxil)

Answer 7

• Highest risk for serotonin syndrome + withdrawal syndromes
• Possibly teratogenic (cleft palate/lip); not recommended in pregnant women
• Interferes with chemotherapuetic Tamoxifen (avoid use in patients undergoing this therapy)
• Adjunctive therapies is best
• More tolerable than TCAs

Question 8

Fluvoxamine (Luvox)

Answer 8

• Shortest half-life of all SSRIs
• Inhibits CYP1A2; smokes may need higher doses to achieve therapeutic effects

Question 9

Nefazodone (Serzone)

Answer 9

Increased risk for severe liver damage

Question 10

Milnacipran (Savella)

Answer 10

Treatment of fibromyalgia

Question 11

Duloxetine (Cymbalta)

Answer 11

Not recommended for bipolar patients; may induce mania

Question 12

Venlafaxine (Effexor)

Answer 12

Increased liability for suicide

Question 13

Mirtazepine (Remeron)

Answer 13

• Increased appetite/weight gain
• Few sexual side effects

Question 14

Amitriptyline (Elavil; TCA)

Answer 14

• Evokes largest analgesic efficacy
• High mortality rates
• Potential for tolerance/dependence (similar to alcohol)

Question 15

Escitalopram (Lexapro, Cipralex, Esopram, Seroplex)

Answer 15

• Found to be more effective than some other antidepressants
• Lower toxicity profile than older antidepressants
• Symptom improvement can be seen as early as 1-2 weeks after use

Question 16

Esketamine (SPRAVATO)