Antiemetics Flashcards Preview

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Flashcards in Antiemetics Deck (12):
1

Metoproclamide (Reglan) drug class

Dopamine receptor antagonist & serotonin (5H3T) receptor agonist

2

Metoproclamide MOA

Blocks D2 receptors in the CRTZ preventing N/V

GI prokinetic effect via serotonin receptor agonism (some increased postsynaptic Ach at muscarinic receptors)

3

Metoproclamide kinetics

30-40% PB, 1-3 minute onset IV, Vd 2-4L/kg, DOA 1-2 hours

Hepatic metab., excreted in urine (40% unchanged). E1/2t 2-4 hrs

4

Metoproclamide SE

Increased gastric motility, LES tone (useful pre-RSI)

Extrapyramidal effects (motor restlessness, tardive dyskinesia)

Abd. cramping, sedation, increased prolactin, dry mouth

5

Metoproclamide CI/Cautions

Parkinsons (especially with Levodopa)

Bowel obstruction, GI bleed

Seizures

Arrhythmias previously on Zofran

6

Metoproclamide dosing

10-20mg IV over 3-5 minutes (give 15 minutes prior to RSI if used for prophylaxis)

7

Ondansetron (Zofran) drug class

Serotonin (5HT3) antagonist

8

Ondansetron MOA

Blocks serotonin receptors in the CRTZ and peripherally

9

Ondansetron kinetics

30 minute IV onset, DOA 4-8hrs

Liver metab., with renal excretion (5%) unchanged. E1/2t 3-4hrs.

10

Ondansetron SE

HA (with rapid admin), sedation, arrhythmias, constipation, diarrhea, fatigue

11

Ondansetron CI/Cautions

Hypersen.

Liver disease

SSRI's

MAOIs

12

Ondansetron dosing

4-8mg IV over 2-5 minutes