Antiemetics Flashcards Preview

Pharmacology > Antiemetics > Flashcards

Flashcards in Antiemetics Deck (15):
1

Examples of Phenothiazine Tranquilizers (3)

1. acepromazine
2. chlorpromazine
3. prochlorperazine

2

General Characteristics of Phenothiazine Tranquilizers (2)

1. block dopamine receptors in the CNS
2. do not prevent vomiting caused by GI irritation

3

Examples of Antihistamines (2)

1. diphenhydramine (Benadryl)
2. dimenhydrinate (Dramamine)

4

General Characteristics of Antihistamines (3)

1. inhibit transmission of nerve impulses from vestibular nerve by blocking histamine receptors
2. can produce a sedative effect
3. affects allergy testing

5

Examples of Anticholinergics (3)

1. aminopentamide (Centrine)
2. isopropamide (Darbazine)
3. Atropine

6

General Characteristics of Anticholinergics (2)

1. blocks nerve conduction through vagus nerve when there's GI irritation (acetylcholine receptors)
2. may decrease GI secretions and GI motility

7

Examples of Serotonin Receptor Antagonists (2)

1. ondansetron (Zofran)
2. dolasetron (Anzemet)

8

General Characteristics of Serotonin Receptor Antagonists (3)

1. block nerve transmission through vagus nerve and prevent stimulation of CRTZ
2. seldom used in animals
3. Human drug mostly

9

Example of Metoclopramide

Reglan

10

General Characteristics of Metoclopramide (3)

1. blocks dopamine receptors in the CNS (CRTZ)
2. also acts locally in GI tract
3. may cause sedation in dogs and excitement in cats

11

How does Metoclopramide act locally in the GI? (3)

1. increases lower esophageal muscle tone
2. causing relaxation of the pylorus
3. increasing GI motility

12

What does Maropitant do? (3)

1. prevents vomiting centrally and locally
2. blocks neurokinin-1 receptors found in GI tract, CRTZ, vestibular nerve, and vomiting center
3. stops all vomiting causes

13

What is Maropitant labeled for use for?

used in dogs to prevent vomiting and motion sickness

14

What effects does Maropitant cause? (3)

1. cough suppressant
2. analgesia properties (GI pain)
3. stings when given SQ

15

What can be done with Maropitant when giving it IV? (2)

1. refrigerate drug
2. give slow

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