Antiepileptic Drugs Flashcards by Лили Ауси

Q

What is the classification of seizures

A

Partial/focal seizures (localized)
Generalized seizures (distributed)

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Q

Example of partial seizures

A

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Q

Example of generalized seizures

A

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Q

Explain tonic phase of seizure

A

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Q

Explain clonic phase of seizures

A

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Q

Explain absence seizures

A

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Q

Explain myoclonic seizures

A

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Q

Explain atonic seizures

A

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Q

Explain status epilepticus

A

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Q

A

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Q

Explain EEG

A

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Q

What does EEG do

A

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Q

What is the main diagnostic application of EEG

A

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Q

How do seizures happen

A

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Q

How to treat seizures

A

Increase GABA
Decrease activity of glutamate

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Q

How is GABA formed

A

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Q

What are the strategies for Antiepileptic drugs

A

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Q

Ideal antiepileptic drugs should

A

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Q

Chemically antiepileptic drugs can classified into what

A

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Q

What are the first generation antiepileptic drugs

A

Hydantoins
Barbiturates
Oxazolidinedione
Succinimides
Carboxylic acid
Carbamazepine
Benzodiazepines

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Q

Hydantoins include what

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A

Phenytoin
Fosphenytoin

Q

Explain Phenytoin

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A

Q

What is the mechanism and pharmacokinetics of phenytoin

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A

Q

Explain phenytoin toxicity

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A

Explain fosphenytoin

What is clinical use of fosphenytoin

Status epilepticus

What are the barbiturates used for epilepsy

Phenobarbital Primidone

Explain phenobarbital

Explain the pharmacokinetics and metabolism of phenobarbital

What are the side effects of phenobarbital

Explain primidone

Explain oxazolidinedione

Explain succinimides with examples

Example of carboxylic acid used for epilepsy

Valproic acid

Exaplin valproic acid

Explain the toxicity, side effects and drug interactions of valproic acid

Explain carbamazepine

Explain metabolism of carbamazepine

Explain the toxicity, side effects and drug interactions of carbamazepine

Explain benzodiazepines for epilepsy

Explain clonazepam

What are the other drugs used for epilepsy

Lamotrigine Topiramate Gabapentin Pregabalin

Explain lamotrigine and its mechanism

What are the side effects of lamotrigine

What is topiramate

What are the clinical uses of topiramate

What is the mechanism of action of topiramate

Explain gabapentin

What is the clinical use of gabapentin

Explain metabolism of gabapentin

Not metabolized and excreted unchanged in urine

Explain pregabalin