Antifungal Flashcards
1
Q
Which of itraconazole, fluconazole, ketoconazole, griseofulvin and terbinafine has the lowest MIC for M. canis and T. mentagrophytes?
A
Terbinafine
2
Q
What molecule gives its resistance to sporothrix against terbinafine ?
A
Melanins: pyomelanin and eumelanin
2
Q
How do antifungal agents (example ketoconazole) help decrease pruritus?
A
Ketoconazole: direct antifungal activity against Malassezia. Like bacteria, Malassezia produces substances that are pruritogenic. These substances also may trigger type I hypersensitivity reactions.
block enzyme 5-lipoxygenase. This enzyme involved in formation of inflammatory cytokines such as LTC4
