Antifungal

Question 1

How do fungi differ from bacteria

Answer 1

Eukaryotes
80S ribsomes compared to 70S
Slow growing
Rigid cell wall

Question 2

Griseofulvin mechanism

Answer 2

Mitotic inhibitor

Question 3

5 Flucytosine use

Answer 3

W/ Amphotericin B to treate Cryptococcal meningitis

Question 4

5 flucytosine mechanism

Answer 4

DNA/RNA synthesis inhibitor

Question 5

Ampho B can be use with

Answer 5

5-FC for Cryptococcal meningitis

Triazoles for synergism/additivity

Question 6

Ampho B drug delivery mechanisms

Answer 6

Fungizone (Better dissolution)
Liposomal (Increase conc., Dec. time, Dec toxicity)
Sterol complex (decrease necrosis)

Question 7

Flucytosine vs Ampho B
Absorption
Solubility
Spectrom 
Toxic
Resistance

Answer 7

Oral vs IV
Soluble vs Not soluble
Narrow spectrum vs wide
Bone marrow depression vs Nephrotoxic
Resistance vs non

Question 8

Specificity of Imidazoles vs Triazoles

Answer 8

Triazoles are more specific

Question 9

Imidazoles

Answer 9

Ketoconazole
Clotrimazole
Miconazole

Question 10

Fluconazole use

Answer 10

Oropharyngeal/vaginal candidiasis

Question 11

Capsofungin mechanism

Answer 11

Inhibition of Beta-1,3 gluan synthase leading to osmotic lysis

Question 12

Tavaborole mechanism

Answer 12

Inhibits Leucyl tRNA synthetase