Antifungal Agents Flashcards
1
Q
Echinocandins
A
caspofungin, micafungin, anidulafungin - inhibit B-glucan synthase in cell wall
* Candida and Aspergillus
2
Q
Allyamines
A
Inhibits squalene epoxidase which makes Ergosterol
- Squalene is toxic
- Can accumulate in the nails making it good for *dermatophyte infections
* Terbinafine
3
Q
Azoles (Imidazoles & triazoles)
A
Inhibit lanosterol 14--demethylase
- Also decrease Ergosterol
- Cytochrome P-450-dependent enzyme
4
Q
Triazoles
A
Greater specificity for fungal p-450 than Imidazoles;
- Fluconazole (Good CNS penetrance), posaconazole & isavuconazole - broad spectrum
* can treat Candidiasis, dermatophytes, endemic mycoses, Cryptococcus neoformans & Aspergillus infections
