Antifungals: Echinocandins and others Flashcards
1
Q
what are the echinocandins
A
- caspofungin
- micafungin
- anidulafungin
2
Q
when are echinocandins used
A
candida including azole resistant, aspergillus
ALL IV ONLY
beta glucan synthase inhibitors
3
Q
ADE echinocandins
A
rare hepatic effects
4
Q
MOA terbinafine
A
squalene epoxidase inhibitor so squalene cannot be made into lanosterol then ergosterol for the cell membrane
5
Q
when to use terbinafine
A
oral or cream for dermatophytes or onychomycosis
6
Q
half life of terbinafine
A
300 hours so accumulates in fat and nails
7
Q
ADE of terbinafine
A
hepatotoxicity (monitor before and after)
8
Q
MOA griseofulvin
A
fungistatic from species of penicillium, binds to tubulin inhibiting the function of the mitotic spindle
9
Q
ADE griseofulvin
A
adverse reaction with ethanol like metronidazole
