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Antivirals & Antifungals > Antiherpes Drugs: Acyclovir > Flashcards

Antiherpes Drugs: Acyclovir Flashcards

1
Q

Acyclovir

A

A nucleoside analog that inhibits the action of viral DNA polymerase and DNA replication of herpes viruses.

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2
Q

MOA

A

Acyclovir triphosphate inhibits viral DNA synthesis by inhibiting viral DNA polymerase and causing DNA chain termination

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3
Q

Pharmacokinetics

A
  • Oral, parental or topical
  • well distibuted and attains good concentration of CSF and aqeous humor
  • Metabolized in liver
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4
Q

Adverse Effects

A
  • nausea
  • rash
  • diarrhea
  • headache
  • irritation
  • burning IV may cause renal or nuero toxicity
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Antivirals & Antifungals (7 decks)

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