Antihistamines

Question 1

Autacoids

Answer 1

Local and sometimes systemic regulators of blood flow and inflammatory process

Question 2

What class of autacoids are we studying

Answer 2

Decarboxylated amino acids

Question 3

Where is histamine made

Answer 3

mast cells, basophils, ECL in GI mucosa, neurons of CNS

Question 4

Metabolism of histamines

Answer 4

Oxidative pathway in liver

Question 5

What sensitivity does histamine play a role in

Answer 5

IgE mediated type I

Question 6

What kind of drug is cisapride

Answer 6

5HT4 and enhance Ach release

Question 7

What kind of drug is mirtazipine

Answer 7

Atypical antidepressant- blocks 5HT2a, 2c, alpha2

Question 8

What kind of drug is fluoxetine

Answer 8

SSRI

Question 9

What kind of drug is Clomipramine

Answer 9

TCA

Question 10

What kind of histamine is meclizine

Answer 10

H1 1st gen

Question 11

What kind of histamine is cyproheptadine

Answer 11

H1 1st gen

Question 12

What kind of histamine is diphenhydramine

Answer 12

H1 first gen

Question 13

What kind of drug is selegeline

Answer 13

Selective MAOb (at higher MAOa as well)

Question 14

What kind of histamine is famotidine

Answer 14

H2

Question 15

What kind of drug is trazodone

Answer 15

5HT2a/2c and weak PreSRI

Question 16

What kind of drug is ondansetron

Answer 16

5HT3 antagonist

Question 17

First gen vs second gen

Answer 17

1st less selective, cross BBB (drowsiness)

Question 18

Diphenhydramine - metabolism

Answer 18

liver, metabolites excreted by urine

Question 19

Diphenhydramine - uses

Answer 19

Anti-emetic, rhinitis, pruritis, allergic derm

Question 20

Cyproheptadine- uses

Answer 20

cat app stim, serotonin syndrome in dogs

Question 21

Meclizine- uses

Answer 21

Motion sickness and anti-emetic, vestibular disorders in dogs; CRTZ

Question 22

Function of H2

Answer 22

gastric secretion

Question 23

Most potent, longest duration H2 blocker

Answer 23

Famotidine

Question 24

Famotidine- metab

Answer 24

Liver, first pass substantial, unchanged in urine

Question 25

Where is 5HT found

Answer 25

Primarily in GI tissue, some in CNS, platelets

Question 26

Serotonin syndroms- cause/effect

Answer 26

Altered serotonin via 5HT receptor- temperature and hemdynamic changes

Question 27

What mediates serotonin degradation

Answer 27

MAO

Question 28

Selegeline- MOA

Answer 28

selective MAOB

Question 29

Selegeline- uses

Answer 29

Canine cognitive dysfunction, cushings

Question 30

Selegeline- SE

Answer 30

GI, CNS excitation or lethargy

Question 31

TCA- example

Answer 31

Clomipramine

Question 32

Common SE of fluoxetine

Answer 32

Appetite reduction/weight loss

Question 33

Mirtazipine- MOA

Answer 33

Blocks 5HT2a/2c, a2's, increase NE transmission

Question 34

Mirtazipine- uses

Answer 34

appetite stim, anti-emetic

Question 35

Trazodone- MOA

Answer 35

Inhibits 5HT2a/2c and weak pre-synaptic SRI

Question 36

Trazodone- uses-

Answer 36

Anxiolytic,

Question 37

Cisapride- MOA

Answer 37

5HT4 agonist with Ach release

Question 38

Cisapride- uses

Answer 38

Gastric motility, megacolon,

Question 39

Ondansetron- uses

Answer 39

anti-emetic dogs

Question 40

Ondansetron- MOA

Answer 40

CRTZ action via 5HT3