Flashcards in Antimalarial Deck (13):
Drugs for P. Falciparum
Antimalarial drug for P. Vivax and P. Ovale but not P. Falciparum
Why can't chloroquine be given to P. Falciparum malaria ?
Malaria drugs that work in acute phase of malarial cycle
Only malarial drug that works in liver phase
Primaquine (for p. Vivax and p. Ovale)
Works during acute phase of malarial cycle
Activated by haem which increases ROS levels
Binds to target and modify proteins resulting in damaged membranes
Usually combined with another drug
What is a 'riamet'?
A regime that consist of artemether (synthetic artemisinin) and lumefantrine (haem polymerase inhibitor)
Mefloquine works at what stage of the malarial cycle
Decrease pyramiding synthesis
- when combined with chloroquine, it can target gametocyte and prevent transmission
Disadvantage of chloroquine
Cannot be used on its own
Not effective against p. Falciparum due to resistance
Concentrates in parasite's lysosomes (site of haemoglobin metabolism) and prevent haem polymerisation.
Haem accumulates and toxicity increase
Mefloquine side effects
Severe psychological side effects