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Flashcards in Antimalarial Deck (13):
1

Drugs for P. Falciparum

Quinine
Mefloquine
Artemisinin

2

Antimalarial drug for P. Vivax and P. Ovale but not P. Falciparum

Primaquine

3

Why can't chloroquine be given to P. Falciparum malaria ?

Resistance

4

Malaria drugs that work in acute phase of malarial cycle

Chloroquine
Quinine
Artemisinin

5

Only malarial drug that works in liver phase

Primaquine (for p. Vivax and p. Ovale)

6

Artemisinin MoA

Works during acute phase of malarial cycle
Activated by haem which increases ROS levels
Binds to target and modify proteins resulting in damaged membranes
Usually combined with another drug

7

What is a 'riamet'?

A regime that consist of artemether (synthetic artemisinin) and lumefantrine (haem polymerase inhibitor)

8

Mefloquine works at what stage of the malarial cycle

Erythrocytic stage

9

Primaquine MoA

Disrupts mitochondria
Decrease pyramiding synthesis

- when combined with chloroquine, it can target gametocyte and prevent transmission

10

Disadvantage of chloroquine

Cannot be used on its own
Not effective against p. Falciparum due to resistance

11

Chloroquine MoA

Concentrates in parasite's lysosomes (site of haemoglobin metabolism) and prevent haem polymerisation.
Haem accumulates and toxicity increase

12

Mefloquine side effects

Severe psychological side effects
Insomnia
Agitation

13

What type of antimalarial drug has no effect on exoerythrocytic stage but is very effective against P. Falciparum

Mefloquine