Antimicrobial chemotherapy

Question 1

Benzylpenicillin G

Answer 1

Penicillin
Acts on Gram+
Best choice for serious pneumococcal, meningococcal and strep pyogenes infection

Question 2

Amoxicillin

Answer 2

Penicillin
Better gram- activity than Benzypenicillin G
Covers streptococci and some coliforms

Question 3

Co-amoxiclav

Answer 3

Penicillin

Covers beta-lactamase producing coliforms

Question 4

Flucloxacillin

Answer 4

Penicillin

Covers beta-lactamase forming staphylococcal infections

Question 5

Action of beta-lactams on bacteria

Answer 5

Inhibition of enzymes involved in synthesis of peptidoglycans

Question 6

PBPs

Answer 6

Enzymes, involved in synthesis of peptidoglycans

Question 7

Cephalosporins

Answer 7

Gram- activity increases from gen. 1-3

Seems to encourage CDI

Question 8

Action of glycopeptides on bacteria + examples

Answer 8

Act only on Gram+ organisms
Inhibit an assembly of the peptidoglycan precursor
Are not absorbed in GI tract
Should inly be given parenterally
Vancomycin+ Teicoplanin

Question 9

Aminoglycosides

Answer 9

Inhibit translation of mRNA at the ribosomes

Question 10

Gentamicin

Answer 10

Is an aminoglycoside
Very good against gram- infections
Called methicillin in lab
methicillin-resistant staph. aureus

Question 11

Macrolides& tetracyclines

Answer 11

Useful alternative for penicillins in treatment of Gram+ infections
Erythromycin
Clarithromycin
Inhibits protein synthesis

Question 12

Oxazolidones

Answer 12

Linezolid
Good activity against MRSA
Inhibits protein synthesis

Question 13

Trimethoprim

Answer 13

Inhibits purine synthesis
used in UTI
less likely than other agents to cause CDI

Question 14

Ciprofloxacin

Answer 14

Is an fluoroquinolone
Inhibits DNA gyrase, which separates DNA inside the nucleus
Effective against Gram- organisms

Question 15

Nalidixic acid

Answer 15

Only effective against Gram - organisms

Urinary antiseptic

Question 16

Nitrofurantonin

Answer 16

Urinary antiseptic

Effective against Gram- and some Gram+