Antimicrobials

Question 1

What is the MOA of cefazolin (Ancef)?

Answer 1

“Inhibits bacterial cell wall synthesis.

Gram + bacilli and cocci,
Gram – rods (proteus mirabili, e.coli, klebsiella pneumonia)

NOT MRSA!”

Question 2

What are the indications of cefazolin (Ancef)?

Answer 2

“Pre op prophylaxis (esp in “clean” surgical procedure) where infection would be catastrophic (immune suppressed, elderly, steroids), and to prevent endocarditis
Cardiovascular, orthopedic/joint, biliary, pelvic, intra=abdominal, skin and soft tissue infections.”

Question 3

What is the onset, PB, E1/2 life, and metabolism of Cefazolin (Ancef)

Answer 3

Give within 1 hr of incision pre op
75% PB
E1/2 life = 90-150mins
80-100% unchanged in urine

Question 4

What are the Adverse Effects of Cefazolin (Ancef)?

Answer 4

“Thrombophlebitis
NVD cramps, oral thrush, colitis
Itching, rash, fever, anaphylaxis, Stevens Johnson synd.
Transient rise in liver enzymes and BUN without damage
Toxic nephropathy, hepatic dysfunction, urticarial,
“

Question 5

What are the contraindications of Cefazolin (Ancef)?

Answer 5

“Hypersensitivity

cross reactivity to penicillin hypersensitivity”

Question 6

What is the dosage of cefazolin (Ancef)?

Answer 6

“250mg-2G q 6-12 hrs (max 12G/day)
One time dose pre op = 1-2g IV 30-60mins prior to incision
Some sx need continual administers Q8 hrs for 24hrs.”

Question 7

What is the drug class of cefazolin (Ancef)?

Answer 7

“First generation cephalosporin
Bactericidal antimicrobial semi synthetic beta-lactam antbx
Broad spectrum”