Antimicrobials Flashcards by Daniel Coquyt

Q

what is the MOA of fluoroquinolones?

A

inhibit DNA topoisomerase II (gyrase) and IV

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Q

what is the MOA of metronidazole?

A

damages DNA

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Q

what is the MOA of rifampin?

A

inhibits mRNA synthesis (RNA pol)

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Q

what is the MOA of the macrolides?

A

inhibits 50S subunit

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Q

what is the MOA of chloramphenicol?

A

inhibits 50S subunit

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Q

what is the MOA of clindamycin?

A

inhibits 50S subunit

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Q

what is the MOA of linezolid?

A

inhibits 50S subunit

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Q

what is the MOA of aminioglycosides?

A

inhibit 30S subunit

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Q

what is the MOA of tetracyclines?

A

inhibit 30S subunit

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Q

what is the MOA of penicilillnase-sensitive penicillins?

A

inhibit pep glycan cross linking

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Q

what is the MOA of penicillinase-resistant penicillins?

A

inhibit pep glycan cross linking

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Q

what is the MOA of antipseudomonals?

A

inhibit pep glycan cross linking

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Q

what is the MOA of cephs?

A

inhibits pep glycan cross linking

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Q

what is the MOA of carbapenems?

A

inhibit pep glycan cross linking

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Q

what is the MOA of monobactams?

A

inhibit pep glycan cross linking

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Q

what is the MOA of glycopeptides?

A

inhibit pep glycan SYNTHESIS

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Q

what are the glycopeptides?

A

bacitracin

- vancomycin

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Q

what is the MOA of the sulfonamides?

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A

inhibit folic acid synthesis

Q

what is the MOA of INH?

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A

inhibits mycolic acid synthesis

Q

what is the MOA of ethambutol?

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A

inhibits arabinoglycan synthesis (arabinosyl transferase)

Q

what is the MOA of rifabutin?

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A

inhibits mRNA synthesis (DNA dependent RNA pol)

Q

what is the MOA of terbinafine?

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A

inhibits lanosterol synthesis

Q

what is the MOA of the echinocandins?

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A

inhibits fungal cell wall synthesis

Q

what is the MOA of the polyenes?

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A

form membrane pores

what is the MOA of flycytosine?

inhibits nucleic acid synthesis

what is the MOA of the azoles?

inhibit ergosterol synthesis

what is the MOA of maraviroc?

inhibits HIV fusion / ATTACHMENT

what is the MOA of enfuvirtide?

inhibits HIV fusion / PENETRATION

abacavir is a(n) ________________

NRTI

efavirenz is a(n) ________________

NNRTI

lamivudine is a(n) ________________

NRTI

tenofovir is a(n) ________________

NRTI

zidovudine is a(n) ________________

NRTI

nevirapine is a(n) ________________

NNRTI

didanosine is is a(n) ________________

NRTI

emtricitabine is a(n) ________________

NRTI

what is the MOA of IFNa?

inhibits protein synthesis

what is the MOA of amantadine and rimantadine?

inhibit viral uncoating

what are the guanosine analogs?

- acyclovir | - gancyclovir

what are the viral DNA pol inhibitors?

- cidofovir | - foscarnet

what is the MOA of ribavirin?

guanine nucleotide synthesis inhibitor

what is the MOA of oseltamivir?

neuraminidase inhibitor

what is the MOA of zanamivir?

neuraminidase inhibitor