Antimicrobials - Macrolides

Question 1

Macrolides Overview

A macrolide is the drug of choice if your patient is allergic to what?

Answer 1

Penicillin

Question 2

Macrolides Overview

Macrolides static or cidal? What is its action?

Answer 2

bacteriostatic, inhibits protein synthesis and thus growth by binding to the 50S ribosome

Question 3

Macrolides Overview

What is the condition called that both macrolides could cause? How?

Going down a slide but its 50ft tall so your heart starts to go crazy an

Answer 3

torsades de pointe
QT phase is prolonged and it creates a heart dysrhythmia, so don’t give if they have a heart issue! (moreso azithromycin!)

Question 4

Macrolides Overview

What are the two macrolide medications?

Answer 4

Erythromycin
Azithromycin

Question 5

Specific

Erythromycin

need to know, SE, taken for

Answer 5

Need to know: also hard on liver so don’t give if they have liver issues
SE: GI upset (C. diff) so N/V
Taken for: if pt. is allergic to penicillin

Question 6

Specific

Azithromycin

need to know, taken for

Answer 6

need to know: newer than erythromycin (Z pack)
taken for: if they have any resp. disorder (acute diphtheria or pertussis)