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Hématologie > Antinéoplasiques > Flashcards

Antinéoplasiques Flashcards

1
Q

Tx contre Lymphome non Hodgkinien

A

RCHOP (Rituximab, Cyclophosphamide, Adriamycine, Vincristine, Prednisone)

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2
Q

Rituximab

A

Anticorps monoclonaux

Anti-CD20
Induction d’apoptose

Réaction anaphylactoïde
Immunosuppression

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3
Q

Cyclophosphamide

A

Agents alkylants

Cross-link ADN bloquant G2
Interfère dans la réplication de l’ARN

Myélosuppression
Cystite hémorragique
Cardiotoxicité

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4
Q

Adriamycine

A

Antibiotiques cytotoxiques

Intercalation dans ADN et liaison à l’enzyme topoisomérase interférant dans la mitose

Myélosuppression
Cardiotoxicité

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5
Q

Vincristine

A

Alcaloïde de la vinca

Inhibition du fuseau mitotique

Vésicant (provoque des ampoules sur la peau)
Neurotoxicité (paresthésie)
Constipation
Syndrome de sécrétion inappropriée d’hormone antidiurétique (hyponatrémie)

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6
Q

Prednisone

A

Corticothérapie

Lyse de lymphoblastes

Intolérance au glucose
Trouble d'humeur, psychose
Ulcère gastrique
Ostéoporose
Hypertension
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Hématologie (2 decks)

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