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Medicine, oncology > Antineoplastic drugs > Flashcards

Antineoplastic drugs Flashcards

1
Q

Which drugs are chemotherapy?

A

Cisplatin
Doxorubicin
Capecytabine

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2
Q

Which drug is hormonal?

A

Tamoxifen

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3
Q

Which drugs are targeted?

A 
Trastuzumab
Cetuximab
Nivolumab
Bevacizumab
Imatinib
Ipilimumab
Vemurafenib
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4
Q

Which drugs are cardiotoxic?

A

Doxorubicin

Traztuzumab

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5
Q

Which drugs are nephrotoxic?

A

Cisplatin

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6
Q

Which side effects does Cisplatin have?

A 
Nephrotoxicity
N/V
Neurotoxicity
Ototoxicity
BM suppression
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7
Q

Side effects of capecytapine?

A

BM suppression
GI symptoms
HAND FOOT syndrome

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8
Q

How is capecytapine adm?

A

Orally

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9
Q

When is capecytapine used?

A

Colorectal and breast cancer

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10
Q

Side effects of Doxorubicin?

A

CARDIOTOXICITY

  • early (arrhythmias
  • late (congestive HF)
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11
Q

Which drug has side effects affecting vessels?

A

Bavacizumab

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12
Q

Mechanism of Tamoxifen?

A

Anti-estrogen

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13
Q

When is tamoxifen used?

A

Breast ca

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14
Q

Administration of Tamoxifen?

A

Oral

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15
Q

Side effects of tamoxifen?

A

Endometrial cancer

Menopausal symptoms

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16
Q

Which drug has red discoloration of urine?

A

Doxorubicin

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17
Q

How long is adjuvant treatment with trastuzumab?

A

1 year

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18
Q

Another name for trastuzumab?

A

Herceptin

19
Q

Mechanism of trastuzumab?

A

Anti-HER2

20
Q

When is trastuzumab used?

A

Breast and gastric ca

21
Q

Side effect of trastuzumab?

A

Cardiotoxicity

22
Q

When is cetuximab used?

A

Colorectal and H/N cancer

23
Q

Mechanism of cetuximab?

A

Binds to EGFR

  • -> inhibits cell growth
  • -> induce apoptosis
24
Q

When is cetuximab ineffective?

A

If present K-ras mutation

25
Q

SIde effects of cetuximab?

A

Skin toxicity = acne like rash

26
Q

What disease is Nivolumab tx for?

A

Melanoma

27
Q

Which drugs can be used in melanoma?

A

Nivolumab
Ipilimumab
Vemurafenib

28
Q

What does nivolumab act on?

A

Lymphocytes

29
Q

Mechanism of nivolumab?

A

Anti-PD1 –> inhibits programmed death

30
Q

Side effect of nivolumab?

A

Autoimmune reactions (CRAZY lymphocytes)

31
Q

When is bevacizumab used?

A

Colorectal ca, ovarian ca

32
Q

Mechanism of bevacizumab?

A

Anti-VEGF

33
Q

Side effects of bevacizumab?

A

HTN
Hemorrhage
Thromboembolism

34
Q

Which stage of colorectal ca is bevacizumab used in?

A

Stage IV

35
Q

Mechanism of Imatinib?

A

Tyrosine-kinase inhibitor

36
Q

Administratoin of Imatinib?

A

Oral

37
Q

When is Imatinib used?

A

CML, GIST

38
Q

Side effects of Imatinib?

A

WELL tolerated

39
Q

Ipilimumab mechanism?

A

CTLA 4-inhibitor = activates T cell

40
Q

When is Ipilimumab used?

A

Melanoma

41
Q

Side effects of ipilimumab?

A

Autoimmune reaction

42
Q

Mechanism of Vemurafenib?

A

BRAF kinase inhibitor

43
Q

Usage of Vemurafenib?

A

Melanoma

44
Q

Side effect of vemurafenib?

A

Skin toxicity

Medicine, oncology (15 decks)

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