Antineoplastics - Hormonal Agents, Signal Transduction Inhibitors, and Miscellaneous

Question 1

glucocorticoid that induces lymphocyte apoptosis

Answer 1

Prednisone

Question 2

MOA: bind to Estrogen receptors and act as agonists/antagonists depending on target tissue

Answer 2

Selective Estrogen Receptor Modulators (SERMS)

Question 3

Pure Estrogen Receptor Antagonist with no agonist activity

Answer 3

Fulvestrant

Question 4

Selective Estrogen Receptor Downregulator (SERD)

Answer 4

Fulvestrant

Question 5

Agonist in non-breast tissues

Answer 5

Tamoxifen

Question 6

Antiestrogen in the uterus and breast

Answer 6

Raloxifene

Question 7

Antagonist in breast

Answer 7

Tamoxifen

Question 8

Chemopreventive agent for women at risk of breast cancer

Answer 8

Tamoxifen

Question 9

Prophylactic for breast cancer in high risk postmenopausal women

Answer 9

Raloxifene

Question 10

agonist at bone to prevent postmenopausal Osteoporosis

Answer 10

Raloxifene

Question 11

SERM that does not cause endometrial hyperplasia

Answer 11

Raloxifene

Question 12

SERM that causes endometrial hyperplasia

Answer 12

Tamoxifen

Question 13

increases ER degradation, reducing number in cells

Answer 13

Fulvestrant

Question 14

used in Tamoxifen-resistant breast cancer

Answer 14

Fulvestrant

Question 15

inhibit Aromatase to prevent Estrone synthesis from Androstenedione

Answer 15

Aromatase inhibitors

Question 16

Non-steroidal Aromatase inhibitors

Answer 16

Anastrozole and Letrozole

Question 17

Steroidal Aromatase Inhibitor

Answer 17

Exemestane

Question 18

Irreversible inhibitor of Aromatase

Answer 18

Exemestane

Question 19

Competitive reversible inhibitors of Aromatase

Answer 19

Anastrozole and Letrozole

Question 20

Androgen Receptor Blocker

Answer 20

Flutamide

Question 21

GnRH analogs

Answer 21

Goserelin and Leuprolide

Question 22

MOA of Flutamide

Answer 22

non-steroidal, competitive antagonist of androgen receptor

Question 23

indications for Flutamide

Answer 23

Prostatic Carcinoma

Question 24

Indications for GnRH analogs

Answer 24

Prostatic Carcinoma

Question 25

stimulate release of FSH and LH from ant. pit

Answer 25

GnRH analogs

Question 26

AE: mild gynecomastia and reversible hepatotoxicity

Answer 26

Flutamide

Question 27

Biphasic response (initial phase/flare and delayed phase)

Answer 27

GnRH analogs

Question 28

Concurrent administration with Flutamide counteracts effects

Answer 28

GnRH analogs

Question 29

inhibits EGFR Tyrosine Kinase; for NSCLC

Answer 29

Gefitinib

Question 30

inhibits EGFR Tyrosine Kinase for colorectal cancer expressing KRAS wild type

Answer 30

Cetuximab

Question 31

EGFR Tyrosine Kinase inhibitor for pancreatic cancer and NSCLC

Answer 31

Erlotinib

Question 32

inhibits EGFR and ErbB2

Answer 32

Lapatinib

Question 33

Humanized monoclonal ab against ErbB2 (HER2)

Answer 33

Trastuzumab

Question 34

Used in breast cancer with HER2 over expression but causes cardiotoxicity

Answer 34

Trastuzumab

Question 35

used for NSCLC and Pancreatic Cancer; inhibits EGFR and ErbB2

Answer 35

Lapatinib

Question 36

inhibits Bcr-Abl in CML

Answer 36

Imatinib

Question 37

inhibits c-kit --> used for GIST

Answer 37

Imatinib

Question 38

Idiopathic Hypereosinophilic Syndrome

Answer 38

Imatinib

Question 39

Inhibits RAF Serine/Threonine Kinase

Answer 39

Sorafenib

Question 40

Used against Renal Cell Carcinoma

Answer 40

Sorafenib

Question 41

Inhibits VEGF-R2, VEGF-R3, and PDGFR-beta

Answer 41

Sorafenib

Question 42

Proteasome inhibitor that inhibits growth and induces apoptosis

Answer 42

Bortezomib

Question 43

Used for Mantle Cell Lymphoma

Answer 43

Bortezomib

Question 44

Inhibits Angiogenesis and VEGFR-1, 2, and PDGFR

Answer 44

Sunitinib

Question 45

Used for Renal Cell Carcinoma and GIST

Answer 45

Sunitinib

Question 46

Used against ALL due to tumor cells lacking exogenous source of L-Asparagine (normal cells have Asparagine Synthase)

Answer 46

Asparaginase

Question 47

AE of Asparaginase

Answer 47

pancreatitis, decreased clotting factors, seizures and coma, hypersensitivity

Question 48

Kills cells in S phase and inhibits Ribonucleotide Reductase, inhibiting DNA Synthesis

Answer 48

Hydroxurea

Question 49

used for Sickle Cell Anemia and Malignant Melanoma

Answer 49

Hydroxyurea

Question 50

AE of Hydroxyurea

Answer 50

Skin hyperpigmentation, macrocytosis, myelosuppression

Question 51

MOA: stimulates NK cells to kill transformed cells by increasing HLA expression on tumor cells

Answer 51

Interferon alpha

Question 52

AE of Interferon alpha

Answer 52

flu-like symptoms

Question 53

Indications of Interferon alpha

Answer 53

Kaposi Sarcoma, Hairy Cell Leukemia, Renal Cell Carcinoma, HPV, HBV, and HCV