Antiparasitic/Antihelmintic Drugs Flashcards
1
Q
What are the use’s of Metronidazole?
A
- Ameibiasis, giardiasis, trichomoniasis, anaerobic bacterial infections
- Co-admin with luminal agent, paromomycin
2
Q
What is the MOA of Metronidazole?
A
Nitro group serves as e-acceptor, forms toxic metabolite that disrupts DNA structure which leads to cell death
3
Q
What are the PK of Metronidazole?
A
- Oral admin
- Hepatic metabolism, excreted in the urine
4
Q
What are the side effects of Metronidazole?
A
N/V, abdominal cramps, metallic taste, seizures, neuropathy, disulfiram effect with alcohol
