Antiparasitics Flashcards
(30 cards)
Antiprotozoal
Chloroquine
Arthemether/lumefantrine
Primaquine
Metronidazole
Paromomycin
Antihelminthic
Albendazole
Ivermectin
Vivax and ovale species of malaria can relase due to
Dormant hypnozoites in the liver
Antimalarial prophylaxis
Chloroquine
Primaquine
Treatment of active or latent malaria
Arthemether/lumefantrine
Chloroquine
Primaquine
Clincical maleria cure (blood stage)
Chloroquine
Artemisinins
Liver stage malaria (radical cure) for relapsin infection
Primaquine
Prophylactic malarial agent properties
Orally effective
Long half lives
Low toxicity
chloroquine mechanism
Inhibits bio crystallization
chloroquine resistance
PfCRT efflux transporter prevents drug accumulation
chloroquine theraputic uses
Prophylaxis
Treatment during pregnancy
High doses of chloroquine may cause
Pruritis
Headache
GI effects
CV toxicity
Artemether (oral) mechanism
Unclear
Not useful for prophylaxis
Artemether uses
In combination with lumefantrine
First line treatment of falciparum
Artemether adverse reactions
Neurotoxicity
Embryotoxicity
Primaquine mechanism
Unknown
Primaquine uses
Perscripted with cloroquine to cure vivax/ovale
For terminal or primary prophylaxis
Primaquine adverse effects
Hemolytic anemia in people with G6PD defiency (contraindicated)
Contraindicated in all pregnant females
_ agents are not absorbed
Luminal
Metronidazole mechanism
DNA damaging metabolite
Metronidazole uses
Systemic
Amebiasis
Anaerobic bacterial infections
Paromomycin mechanism
Aminoglycoside
Paromomycin uses
Luminal
Asymptomatic amebiasis
Amebic colitis/dysentery
Alternative to metrondiazole in pregnancy
Leshmanias
Paromomycin adverse effects
GI distress
