AntiPhospholipid Syndrome Flashcards Preview

MSK 2 > AntiPhospholipid Syndrome > Flashcards

Flashcards in AntiPhospholipid Syndrome Deck (16)
Loading flashcards...
1
Q

clinical manifestations of APS

A

recurrent arterial or venous thrombotic disease and/or recurrent fetal loss

2
Q

patho of APS

A

autoantibody production against cell membrane phosopholipids

3
Q

types of APS

A
  1. primary APS

2. secondary APS (APS + rheumatic dz)

4
Q

mc associated rheumatic dz in APS

A

SLE

5
Q

other commonly associated diseases with APS

A

Sjogren’s and RA

6
Q

diagnosis of APS req/

A

one clinical (thrombosis or pregnancy) and one laboratory criteria

7
Q

APS associated clinical features

A
cardiac valve dz
lived reticularis 
nephropathy 
thrombocytopenia 
neuro manifestations
8
Q

vascular thrombosis criteria

A

one or more clinical episodes of arterial, venous, or small vessel thrombosis

9
Q

pregnancy morbidity

miscarriage

A

one or more late term (>10 weeks gestation) OR 3 or more unexplained consecutive early (<10 weeks) spontaneous abortions

10
Q

pregnancy morbidity

placenta

A

premature birth of morphologically healthy neonate at or before 34 weeks bc of severe preeclampsia, eclampsia, severe placental insufficiency

11
Q

laboratory criteria

A

anti-cardiolipin antibodies

anti-beta 2 glycoprotein I antibodies

lupus anti-coaglulant

12
Q

when to suspect APS

A

thrombotic disease (micro and macro) 0 young pts w/o risk factors or recurrent

hematologic dz

cutaneous manifestations

neuro dz

13
Q

what might cause second hit of APS

A

virchow’s triad

14
Q

therapeutics of APS

A

eliminate other risk factors (estrogen, smoking, HTN, hyperlipidemia)

Low dose aspirin

hydroxychloroquinine

15
Q

if thrombosis occurs management:

A

LMWH or UF Heparin

tailor lifelong with patient

target INR 2-3 (If warfarin)

16
Q

APS and pregnancy

A

pts with hx of pregnancy loss receive low dose ASA/heparin

given thru pregnancy and held at time of delivery thru 6-12 weeks post partum