Antipsychotic drugs

Question 1

high potency drugs TYPICAL

Answer 1

Haloperidol Fluphenazine Trifluoperazine
Prochlorperazine

Question 2

Low potency drugs TYPICAL

Answer 2

Chlorpromazine Thiothixene thioridazine

Question 3

EPS

Answer 3

Neuroleptic -malignant syndrome
Acute dystonia
Perioral tremors
Parkinsonism
Tardive dyskinesia
Akathisia

Question 4

Akathisia R/

Answer 4

Propranolol
Diphenhydramine Benzodiazepine, clonazepam or diazepam

Question 5

Parkinson-like symptoms R/

Answer 5

antimuscarinic drug: trihexyphenidyl, procyclidine, benztropine

Question 6

Perioral Tremors R/

Answer 6

antimuscarinic drug: trihexyphenidyl, procyclidine, benztropine

Question 7

Neuroleptic Malignant Syndrome R/

Answer 7

IV Dantrolene (muscle relaxant) (DOC),or bromocriptine ( D2 agonist)

Question 8

Acute dystonia

Answer 8

Rx: IM antihistaminic-anticholinergic
(Diphenhydramine or Promethazine)

Question 9

Tardive dyskinesia

Answer 9

Irreversible- treatment unsuccessful

Question 10

Atypical antipsychotic

Answer 10

Clozapine
❑ Olanzapine
❑ Quetiapine
❑ Asenapine
❑ Risperidone
❑ Ziprasidone
❑ Paliperidone
❑ Amisulpride
❑ Aripiprazole
❑ Brexipiprazole
❑ Cariprazine

Question 11

Clozapine ADR

Answer 11

Agranulocytosis
▪ Sedation
▪ Weight Gain
▪ Paradoxical hypersalivation
▪ Risk diabetes
▪ Low seizure threshold
▪ Myocarditis, Constipation

Question 12

Risperidone

Answer 12

hyperprolactinemia (galactorrhoea, gynaecomastia),
▪ EPS at high doses
▪ weight gain, postural hypotension, cardiac arrythmia

Question 13

Olanzapine

Answer 13

▪ Few EPS, Weight gain
▪ Risk of hyperlipidemia
▪ New onset of diabetes mellitus, seizure

Question 14

Ziprasidone

Answer 14

QT prolongation

Question 15

Quetiapine

Answer 15

Drowsiness, headache, orthostatic hypotension and weight gain, Drug interaction with antifungals, macrolides, anticonvulsants.

Question 16

Aripiprazole

Answer 16

-EPS
▪ Prolongs QTc interval ▪ Weight gain
▪ Hyperglycemia
▪ Hypotension