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Psychiatry > antipsychotic farm > Flashcards

antipsychotic farm Flashcards

antipsychotic pharm

1
Q

chlorpromazine drug class

A

typical anti-psychotic

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2
Q

perphenazine drug class

A

typical anti-psychotic

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3
Q

haloperidol drug class

A

typical anti-psychotic

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4
Q

fluphenazine drug class

A

typical anti-psychotic

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5
Q

antipsychotics work best w/ positive or negative symptoms of schizo?

A

postiive

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6
Q

Positive symptoms of schizophrenia arise from

A

increased DA in Nacc

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7
Q

negative symptoms in schizo arise from

A

decreased DA in PFC

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8
Q

typical antipsychotic side effects

A

dystonia, parkinsonism, prolactin release, anti-cholinergic, rigidity, stiffness

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9
Q

major symptoms of neuroleptic malignant syndrome

A

fever, rigidity, elevated CPK

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10
Q

minor symptoms of neuroleptic malignant syndrome

A

tachycardia,tachypnea, abnormal BP, altered consciousness, sweating

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11
Q

major mechanism of atypical antipsychotics

A

release of dopamine in prefrontal cortex

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12
Q

clozapine drug class

A

novel/atypical antipsychotic

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13
Q

risperidone drug class

A

novel/atypical antipsychotic

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14
Q

olanzapine drug class

A

novel/atypical antipsychotic

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15
Q

quetiapine drug class

A

novel/atypical antipsychotic

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16
Q

ziprasidone drug class

A

novel/atypical antipsychotic

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17
Q

aripiprazole drug class

A

novel/atypical antipsychotic

18
Q

paliperidone drug class

A

novel/atypical antipsychotic

19
Q

iloperidone drug class

A

novel/atypical antipsychotic

20
Q

asenapine drug class

A

novel/atypical antipsychotic

21
Q

lurasidone drug class

A

novel/atypical antipsychotic

22
Q

brexpiprazole drug class

A

novel/atypical antipsychotic

23
Q

clozapine drug class

A

novel/atypical antipsychotic

24
Q

t/f clozapine causes agranulocytosis

A

t

25
Q

clozapine mechanism

A

weak DA D2 antagonism, potent serotonin and a2 antagonism potentially increases norepi

26
Q

risperidone mechanism

A

weak DA D2 antagonism, potent serotonin and a2 antagonism

27
Q

clozapine side effects

A

agranulocytosis
seizures
myocarditis
weight gain, glucose,and lipid dysregulation
tachycardia, hypotension
drooling
sedation
liver function changes

28
Q

Risperidone side effects

A

EPS in higher doses and prolactin elevation

29
Q

olanzapine mechanism

A

weak DA D2 antagonism, potent serotonin and a2 antagonism

30
Q

olanzapine side effects

A

weight gain, glucose/lipid dysregulation, sedation

31
Q

Quetiapine/ Seroquil mechanism

A

weak DA D2 antagonism, potent serotonin and a2 antagonism

32
Q

Quetiapine/ Seroquil side effects

A

minimal

33
Q

aripiprazole mechanism

A

partial dopamine agonist fixes problem w/ underactive prefrontal cortex and overactive area below it ie antagonist in conditions of hyperactivity and agonist in conditions of hypoactivity

34
Q

Aripiprazole side effects

A

low weight gain
early activation from agonist effect, insomnia

35
Q

All typical and atypical antipsychotics are blockers of which receptor?

A

D2

36
Q

benefits of atypical antipsychotics

A

less EPS, less prolactin elevation (except resperidone and palperidone), improved efficacy, less relapses, helpful in negative symptoms

37
Q

which atypical antipsychotic is useful for suicidal patients and substance use

A

clozapine

38
Q

relationshiop of Glutatmate w/ psychosis

A

NMDA antagonisits produce positive and negative symtpoms

39
Q

mechanism of typical anipsychotics

A

DAD2 blockade

40
Q

2 high potency typical antipsychotics

A

haloperidol and fluphenazine

Psychiatry (4 decks)

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