Antipsychotic medications Flashcards
Risperidone (Risperdal)
Anti psychotic (mood stabilizer)
Use for Schizophrenia
or Short term tx of acute manic or BP 1 disorder, can be used with lithium or valproate (adults only)
Has markedly fewer side effects than traditional agents
Should not be discontinued abruptly
Watch for signs of infection, such as fever,
Olanzapine (Zyprexa)
Antipsychotic
Mood stabilizer
Thienobenzodiazepines
Indications: Schizophrenia
BP1
Produces fewer extrapyramidal symptoms than do traditional antipsychotics.
Poses an increased risk of orthostatic hypotension when used with antihypertensives, alcohol, or benzodiazepines.
Monitor for fever, lethargy, weakness, or sore throat.
Unlabeled use:
anorexia nervosa
Tx for N/V
Symbyax (Olanzapine/Fluoxetine)
was approved by the FDA as the first medication for treatment of bipolar depression.
Administered once daily night, usually beginning with 6mg/25 mg capsule
Quetiapine (Seroquel)
Antipsychotic
Mood stabilizer
Indications: Schizophrenia
Depressive episodes with bipolar disorder
Acute manic episodes BP1
Lorazepam and antihypertensives increase the effects of quetiapine.
Has the adverse effects of somnolence and orthostatic hypotension.
Not safe during pregnancy.
Monitor for sore throat, fever, unusual bleeding or bruising, rash, weakness and tremors,
Side effects of Antipsychotics
Drowsiness Nausea Salivation Akathisia Dyskinesias Dystonia Neuroleptic Malignant Syndrome Pseudoparkinsonism
Low potency typical antipsychotics can be used in cases of schizophrenia combined with severe depression True or False?
False
Severe depression is one of the contraindications for low-potency typical antipsychotics.
Typical Antipsychotic MOA
MOA: Blocks dopamine receptors in the brain
Thioridazine MOA
MOA: Depresses the parts of the brain involved with wakefulness and emesis.
Risperidone MOA
What is its action?
MOA: Blocks dopamine and serotonin receptors in the brain.
Clozapine (Clozaril)
Can be given during pregnancy
Produces little to no TD tardive dyskinesia
Avoid for clients with low WBC count (it suppresses development of WBC’s
Chlorpromazine
if taken with alcohol the following can occur:
CNS depression and hypotension can occur if clients take chlorpromazine with barbiturate anesthetics, alcohol, or meripidine.
Neuroleptic Malignant Syndrome
is the most serious and potentially fatal side effect of high potency anti psychotics. S/S of NMS are: severe muscular rigidity altered consciousness dysphagia stupor or catatonia
Haloperidol contraindicated in….
blood dyscrasia
compromised renal function
Parkinson’s disease
Antipsychotic (neuroleptic) medications are used to treat
severe thought disorders such as schizophrenia. They also are used for acute and chronic confusion that commonly accompanies psychoses, extreme aggression and dementia. Antipsychotics are subdivided into typical (traditional) and atypical subclasses.
Antipsychotic target symptoms include
disorganized speech and behavior, flat or inappropriate effect, delusions, hallucinations, and dementia.
