ANTIPSYCHOTICS Flashcards
Chlorpromazine, Thioridazine
1st Generation- Low Potencty Agent
Fluphenazine, Haloperidol
1st Generation- High Potency
Low Potency= __ sedation + __ AcH + __ EPS
HIGH sedation, HIGH AcH, LOW EPS
High Potency= __ sedation + __ AcH + __ EPS
LOW sedation, LOW AcH, HIGH EPS
1st generation effects which NT?
dopamine
How long does it take for antipsychotics to take effect?
2-6 weeks
1st Generation used for what sx
positive sx
1st Generation- AE
EPS, sedation, orthostatic HT, sexual dysfunction, weight gain, seizure-vulnerability, tardive dyskinesia
EPS Sx
Dystonia (contraction of muscles), Akathisia (restlessness/inability to stay still), Psuedoparkinsonism (tremors, weak gait, reduced facial expressiveness)
Tx for EPS
Diphenhydramine, Benzotropine
Clozapine, Risperidone, Paliperidone, Olanzapine, Ziprasidone, Lurasidone, Quetiapine
2nd Generation Antipsychotics
2nd Generation Tx used for what Sx
positive & negative
2nd Generation- AE
sedation, weight gain, sexual dysfunction
2nd Generation increased risk for what ___ syndrome
metabolic syndrome
Sx of Metabolic Syndrome
weight gain, insulin resistance, increased blood glucose, dyslipidemia, increased risk for diabetes, HT, cardiovascular disease
Clozapine increases risk for what
severe neutropenia (<500/UL)
Risperidone CI in who
dementia patients
What do you monitor in Ziprasidone?
BP & QT waves
Anticholinergic Toxicity- Sx
dilated pupils, confusion, urinary retention, reduced peristalsis, altered mental statues
Anticholinergic Toxicity- Tx
Hold all medication
NTP
Cooling agents
Physostigmine used to reverse what
Anticholinergic Toxicity
What do you evaluate when psychosis is worsening?
Anticholinergic Toxicity
Neuroleptic Malignant Syndrome is seen in which medication?
Haloperidol
NMS- Sx
muscle fidgety, fever, reduced consciousness, sweating, altered mental status
