Antipsychotics

Question 1

Atypical antipsychotics

Answer 1

Aripipazole Risperidone Clozapine Olanzapine Quetiapine Ziprasidone

Question 2

Retinal pigmentation

Answer 2

Thioridazine

Question 3

Treatment for tardive dyskinesia?

Answer 3

Stop drug! Switch to atypical. Cholinomimetic, benzos, or beta blockers short term

Question 3

Monitor LFTs

Answer 3

Olanzapine

Question 4

Decanoate forms available

Answer 4

Haloperidol Fluphenazine

Question 4

Atypical with highest risk for EPS

Answer 4

Risperidone

Question 5

Atypical vs. typical: Better for positive symptoms

Answer 5

Same efficacy

Question 6

Eye exams needed

Answer 6

Quetiapine, chlorpromazine (cataracts, corneal/lens deposition)

Question 7

QTc prolongation

Answer 7

Ziprasidone, thioridazine

Question 8

EPS > 6 months

Answer 8

Parkinsonsim

Question 9

Blue-gray skin discoloration

Answer 9

Chlorpromazine

Question 9

Highest incidence of akathesia

Answer 9

Aripiprazole

Question 10

High-potency typicals

Answer 10

Haloperidol Trifluoperazine Fluphenazine Perphenazine Pimozide

Question 11

Tx acute dystonia

Answer 11

Benadryl, benztropine

Question 12

Weight neutral

Answer 12

Aripriprazole Ziprasidone

Question 13

Tx parkinsonism

Answer 13

Benztropine, amantadine, bromocriptine

Question 14

What causes tardive dyskinesia?

Answer 14

Increase in number of DA receptors in response to AP results in less ACh

Question 15

EPS < 12 hours

Answer 15

Acute dystonia

Question 16

Side effects more common with high potency antipsychotics

Answer 16

EPS (Parkinsonism, dystonia, akathisia) Tardive dyskinesia NMS

Question 17

Tx akasthesia

Answer 17

Propanolol (first line) Benzo

Question 19

Dopamine antagonizes which two substances?

Answer 19

ACh and prolactin

Question 20

Low-potency traditonals

Answer 20

Chlorpromazine Thioridazine

Question 20

Patients at highest risk for NMS?

Answer 20

Males who just began taking med

Question 22

Atypical vs typical: Better with negative symptoms

Answer 22

Atypical

Question 24

Least weight gain of atypicals

Answer 24

Quetiapine

Question 24

Atypical with highest risk for hyperprolactinemia

Answer 24

Risperidone

Question 25

Orthostasis

Answer 25

Quetiapine

Question 26

MOA: atypical vs typical antipsychotics

Answer 26

Typical- D2 antagonism Atypical- D2 and 5HT2 antagonism

Question 26

EPS 30-90 days

Answer 26

Akasthesia

Question 27

When does tardive dyskinesia begin?

Answer 27

\> 6 months after starting med

Question 28

Need weekly blood draws

Answer 28

Clozapine (agranulocytosis)

Question 30

Seizures

Answer 30

Clozapine Low potency typicals (chlorpromazine and thioridazine) are more likely than high potency

Question 31

Patients at highest risk for tardive dyskinesia

Answer 31

Older women on Rx \> 6 months

Question 33

Typical antipsychotics

Answer 33

Haloperidol Chlorpromazine Thioridazine Trifluoperazine

Question 34

Lens and corneal deposits

Answer 34

Chlorpromazine

Question 36

Most common side effect of olanzapine

Answer 36

Sedation

Question 37

EPS \> years

Answer 37

Tardive dyskinesia

Question 38

Treatment of EPS?

Answer 38

Benztropine (anticholinergic), amantadine (flu Rx, M2 inhibitor), or benzos

Question 39

What is the cause of sexual dysfunction seen with some ADs and APs?

Answer 39

Alpha blockade

Question 40

Agranulocytosis

Answer 40

Clozapine (or mirtazapine if AD)