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Flashcards in Antipsychotics Deck (18):
0

Thorazine

Chlorpromazine
1st gen
Phenothiazine
Low potency (decreased eps)

1

Prolixin

Fluphenazine
1st gen
Phenothiazine
High potency (increased eps)

2

Haldol

Haloperidol
1st gen
Butyrophenone
High potency

3

Loxitane

Loxapine
1st gen
Benzazepine

4

Trilafon

Perphenazine
1st gen
Phenothiazine--> structural derivative of fluphenazine

5

Mellaril

Thioridazine
1st gen
Phenothiazine
Worst for QT prolongation

6

Stelazine

Trifluoperazine
1st gen

7

Navane

Thiothixene
1st gen
Thioxanthene ->sterioisomerism
BBW: dementia related psychosis

8

Abilify

Aripiprazole
2nd gen
Quinolone derivative
Partial D2 agonist and 5-HT2 antagonist
Dose:10-15mg
2D6,3A4
Maintena inj q month and 2 week overlap

9

Saphris

Asenapine
2nd gen
Benzazepine
Dose:10-20mg
Glucuronidation, 1A2
Do not eat or drink for 10 min after SL dose

10

Clozaril

Clozapine
2nd gen
Benzazepine
Dose:300-450mg
1A2
MACES
Restricted drug
Metabolic syndrome

11

Fanapt

Iliperidone
2nd generation
Benzisoxazole
Dose:12-24mg
2D6,3A4
Must trilateral dose up due to dose dependent orthostasis risk. If 3or more days missed re initiate titration

12

Latuda

Lurasidone
2nd generation
Dose:40-80mg
3A4
5-HT7 ->improved cognitive sxs
Take with a meal >350 calories

13

Invega

Paliperidone (racemic mix of risperidone metabolites)
2nd generation
Benzisoxazole. Active metabolite of risperidone
Dose:3-12mg
Non-CYP
Shell may appear in stool
Invega sustenna inj q month (loading dose) no overlap

14

Zyrprexa

Olanzapine
2nd gen
Benzazepine
Dose:10-20mg
1A2
Zyrprexa relprevv ing q 2-4 weeks
BBW FOR POST INJECTION Delirium
Worst drug for metabolite syndrome

15

Seroquel

Quetiapine
2nd gen
Benzazepine
Dose:150-800mg
3A4
Should take XR formulation w/o food or <300 calories

16

Risperidal

Risperidone
2nd gen
Benzisoxazole
Dose:2-8mg
2D6
Risperidal consta inj q2weeks and overlap for 3 weeks

17

Geodon

Ziprasidone
2nd gen
Benzisothiazole
Dose:40-100mg
3A4
Worst for QT prolongation
Take with food >500 calories