Antipsychotics Flashcards
(15 cards)
One example of a high potency antipsychotic is _____.
Haloperidol
One example of a low potency antipsychotic is _____.
Thioridazine
The only antipsychotic which is relatively selective for D4 is
Clozapine
Treatment of the adverse effect of tardiness dyskinesia is opposite to that of
Parkinsonian symptoms
A blockade of 5HT2 may _______ in schizophrenia patients.
Improve negative symptoms
Differences between typical and atypical antipsychotics (2)
Typical only block D2 receptors while atypicals block 5HT as well.
Atypicals have fewer negative symptoms and fewer extrapyramidal side effects.
Major Adverse effect of clozapine?
Agranulocytosis
What to give for extrapyramidal side effects of typical antipsychotics?
Tetrabenzine, diphenhydramine, benztropine
Long term Mechanism of tardive dyskinesia
Dopamine receptor up regulation
Thioridazine can cause ________ of the heart
Torsade de Pointes/ long QT
Metabolism of Atypicals
Hepatic metabolism P450
The Tuberal-infundibular system controls
Prolactin
Atypicals strongly affect which projection in the brain?
Mesocortical projection
Low potency typicals have more ________ side effects
Anti-cholinergic
Blocking D2 causes increase in
cAMP
