Antipsychotics (Typical & Atypical)

Question 1

What is the main mechanism of action for antipsychotics?

Answer 1

Block dopamine D2 receptors (some also block serotonin 5HT2A)

Question 2

What’s the difference between first-generation and second-generation antipsychotics?

Answer 2

• First-gen (FGAs) = Strong D2 blockade → more EPS
• Second-gen (SGAs) = D2 + 5HT2A blockade → fewer EPS, better for negative symptoms

Question 3

What symptoms of schizophrenia do FGAs treat best?

Answer 3

Positive symptoms (e.g., hallucinations, delusions)

Question 4

What symptoms do SGAs treat better than FGAs?

Answer 4

Negative symptoms (e.g., flat affect, social withdrawal)

Question 5

What is the brand name of haloperidol?

Answer 5

Haldol

Question 6

What is the generic name of Haldol?

Answer 6

Haloperidol

Question 7

Which FGA has the highest risk of EPS?

Answer 7

Haloperidol (Haldol)

Question 8

What is a low-potency FGA that causes more sedation, anticholinergic effects, and hypotension?

Answer 8

Chlorpromazine (Thorazine)

Question 9

What is the brand name of chlorpromazine?

Answer 9

Thorazine

Question 10

What is the generic name of Thorazine?

Answer 10

Chlorpromazine

Question 11

What is the brand name of risperidone?

Answer 11

Risperdal

Question 12

What is the generic name of Risperdal?

Answer 12

Risperidone

Question 13

What is the brand name of olanzapine?

Answer 13

Zyprexa

Question 14

What is the generic name of Zyprexa?

Answer 14

Olanzapine

Question 15

What is the brand name of quetiapine?

Answer 15

Seroquel

Question 16

What is the generic name of Seroquel?

Answer 16

Quetiapine

Question 17

What is the brand name of aripiprazole?

Answer 17

Abilify

Question 18

What is the generic name of Abilify?

Answer 18

Aripiprazole

Question 19

What is the brand name of ziprasidone?

Answer 19

Geodon

Question 20

What is the generic name of Geodon?

Answer 20

Ziprasidone

Question 21

What is the brand name of lurasidone?

Answer 21

Latuda

Question 22

What is the generic name of Latuda?

Answer 22

Lurasidone

Question 23

What is the brand name of clozapine?

Answer 23

Clozaril

Question 24

What is the generic name of Clozaril?

Answer 24

Clozapine

Question 25

Which SGA has the highest risk of metabolic syndrome (weight gain, diabetes)?

Answer 25

Olanzapine (Zyprexa)

Question 26

Which SGA is best for treatment-resistant schizophrenia?

Answer 26

Clozapine (Clozaril)

Question 27

What are clozapine’s serious side effects?

Answer 27

Agranulocytosis, seizures, myocarditis, weight gain

Question 28

Which SGA has the highest risk of prolactin elevation and EPS at high doses?

Answer 28

Risperidone (Risperdal)

Question 29

Which SGA is least likely to cause weight gain or sedation?

Answer 29

Aripiprazole (Abilify)

Question 30

What is the major risk of ziprasidone (Geodon)?

Answer 30

QT prolongation

Question 31

Blocking which pathway causes EPS?

Answer 31

Nigrostriatal dopamine pathway

Question 32

Blocking which pathway causes prolactin elevation?

Answer 32

Tuberoinfundibular dopamine pathway

Question 33

Blocking mesolimbic D2 receptors improves what?

Answer 33

Positive symptoms of schizophrenia

Question 34

What receptor action is linked to metabolic side effects in SGAs?

Answer 34

H1 and 5HT2C blockade

Question 35

What are examples of long-acting injectable antipsychotics?

Answer 35

• Haldol Decanoate (haloperidol) • Invega Sustenna (paliperidone) • Risperdal Consta (risperidone) • Abilify Maintena (aripiprazole) • Aristada (aripiprazole) • Zyprexa Relprevv (olanzapine)

Question 36

Which LAI has a BBW for post-injection delirium/sedation syndrome?

Answer 36

Zyprexa Relprevv (olanzapine)

Question 37

Why are LAIs useful in schizophrenia treatment?

Answer 37

Improve medication adherence and reduce relapse risk