Antispastice intestinale

Question 1

Tipuri de antispastice

Answer 1

Anticolinergice

Musculotrope (papaverinice)

Question 2

Antispastice anticolinergice - mecanism de actiune

Answer 2

Blocarea RM3 de pe musc neteda

Question 3

Indicatii antispastice anticolinergice

Answer 3

SII
Diskinezii/ stari spastice gastrice, duodenale, intestinale
Enurezis nocturn, hipertonie vezicala
Colici reno-ureterale

Question 4

Anticolinergice - RA

Answer 4

xerostomie, disfagie, dificultati in vorbire
constipatie
tulburari de vedere
agravare glaucom
mictiuni dificile, retentie acuta de urina
tk, aritmii
sedare

Question 5

Anticolinergice - CI

Answer 5

Glaucom
Adenom de prostata
FiA, IC
Constipatie

Question 6

Anticolinergice - reprezentanti

Answer 6

Atropina si scopolamina
Dyciclomina si hyosciamina
Bromura de butilscopolamina
Propantelina
Oxifenoniu
Bromura de clidiniu si de otiloniu

Question 7

Antispastice musculotrope

Answer 7

Papaverina
Mebeverina
Drotaverina
Alverina
Pitofenona

Question 8

Papaverina - mecanism de actiune

Answer 8

Inhibitia neselectiva a fosfodiesterazelor si cresterea cAMP, blocarea neselectiva a canalelor de Ca -> relaxarea musculaturi netede + VD

Question 9

Papaverina - indicatii

Answer 9

Colici biliare, intestinale, reno-ureterale

Dismenoree

Question 10

Papaverina - RA

Answer 10

Congestia fetei
Somnolenta
Cresterea transaminazelor
La injectare rapida iv - aritmii, BAV

Question 11

Papaverina - CI

Answer 11

HTIC

BAV

Question 12

Mebeverina - mecanism de actiune

Answer 12

blocarea canalelor de Na, K, Ca mb la niv fb musc netede

Question 13

Mebeverina - indicatii

Answer 13

colopatii functionale
SII
stari de hipermotilitate

Question 14

Drotaverina - mecanism de actiune

Answer 14

Antispastic
Vasodilatator
Slab blocant al Rbeta1

Question 15

Drotaverina - indicatii

Answer 15

Colici intestinale si biliare

Afectiuni vasculo-spastice

Question 16

Alverina - indicatii

Answer 16

SII + simeticona

Dismenoree

Question 17

Piafen

Answer 17

Pitafenona + fenpiramida (antispastic anticolinergic) + metamizol (analgezic)

Question 18

Trimebutina - mecanism de actiune

Answer 18

Reglator al motilitatii digestive (actiune duala) prin + R opioizi miu, kappa, delta
Analgezic local (blocarea canalelor de Na) - amelioreaza durerea din SII
X canalelor de Ca de tip L
X canalelor de K

Question 19

Trimebutina - indicatii

Answer 19

Dispepsii functionale
SII
Constipatia idiopatica
Patologie mixta (SII + BRGE sau dispepsie functionala)
Diskinezii biliare hipotone
Afectiuni organice ale TGI
Copii: colici, abdomen dureros, tulb de tranzit

Question 20

Trimebutina - CI

Answer 20

Legate de excipienti (lactoza) - sdr de malabsorbtie (galactozemie congenitala, malabsorbtia glu, deficit de lactaza)