Antivirals

Question 1

Zanamivir, Oseltamavir

Answer 1

MOA: Neuraminidase Inhibitor (viral release)
Use: Influenza A and B

Question 2

Ribavirin

Answer 2

MOA: Guanine analog, inhibits synthesis
Use: RSV, HCV
SE: hemolytic anemia, TERATOGEN

Question 3

Acyclovir

Answer 3

MOA: Thymidine Kinase activates, inhibits DNA polymerase (replaces Guanosine)
Use: HSV/VZV
SE: crystalline nephropathy

Question 4

Ganciclovir

Answer 4

MOA: CMV viral kinase activated, DNA Polymerase inhibition
Use: CMV
SE: Leukopenia, thrombocytopena, Renal toxicity

Question 5

Foscarnet

Answer 5

MOA: Viral DNA polymerase inhibitor
Use: CMV retinitis, resistant HSV
SE: Nephrotoxic

Question 6

Cidofovir

Answer 6

MOA: Inhibit DNA polymerase
Use: CMV retinitis, Resistant HSV
SE: Nephrotoxic (must give with probenecid)

Question 7

Protease Inhibitors (-navir)

Answer 7

MOA: Inhibit HIV protease
Use: HIV HAART
SE: Lipodystrophy (hyperglycemia, HTG), hematuria

Question 8

NRTI (-vudine, didanosine, abacavir)

Answer 8

MOA: Inhibit HIV reverse Transcriptase
Use: HAART HIV
SE: Bone Marrow Suppression, Pancreatitis

Question 9

NNRTI (efavirenz, nevirapine, delavirdine)

Answer 9

MOA: Inhibit RT
Use: HAART
SE: Rash, CNS, dreams

Question 10

Raltegravir

Answer 10

MOA: Integrase inhibitor HIV
Use: HIV
SE: HCL

Question 11

Enfuvirtide, Maraviroc

Answer 11

MOA: HIV fusion inhibitor

Question 12

Interferons

Answer 12

MOA: antiviral.anti tumor
Use: Alpha: HBV, HCV, Beta: MS, Gamma: CGD