Antivirals Flashcards Preview

Pharm Final antibiotics/fungals > Antivirals > Flashcards

Flashcards in Antivirals Deck (32):
1

what is the combo of tenofovir and emtricitabine used for

pre exposure prophylaxis
post exposure prophylaxis

2

what are some adverse effect of emtricibabine

hyperpigmentation of the palms and skin discoloration

3

what are the adverse effects with Zidovudine

bone marrow supression

4

what are special consideration for lamivudine

Epirvir HBV
resistance is quite common

5

What is truvada

emtricitabine and tenofovir
1 tab PO dialy

6

what is atripla

emtricitabine, tenofovir, efavirenz
1 tab PO daily

7

What is stribild

emtracitabine, tenofivir, elvitegravir, cobivistat
1 tab PO dialy

8

What is dosing like for efaviranz

600mg PO at bed time

9

How should you take efaviranz

empty stomach

10

what are the averse effects with Efaviranz

CNS effects
stops after 2-4 wks
rash
increased LFT
Teratogen
false positive weed test

11

what is rilpivirine not used for and what should you avoid using it with?

high viral loads
Proton pump inhibitors

12

what are some adverse effects with Nevirapine

hepatits and fetal hepatic necrosis

13

What are the special considerations with Atazanavir and what are the adverse effects

avoid with proton pump inhibtors

indirect hyperbiliruninemia
lack of effects on lipids

14

what is a special precautions with Darunavir

caution with sulfa allergy
Rash

15

what are the adverse effects with Raltegravir& Stribild

increased creatine kinase

16

when do antivirals need to be administered for HSV and VZV

Acyclovir
48-72hr with onset of rash

17

what is the blackbox warning with Ganciclovir
what are the special considerations

treats CMV
bone marrow tox
Hydrate aggressively
monitor renal function
avoid skin contact alkaline and teratogenic

18

what is the the drug of choice for Tx and Px of CMV

Valganciclovir

19

what are the special considerations with Valganciclovir

PO only
look alike sound alike with Valcyclovir and Valganciclovir

20

what is the adverse effect with Foscarnet what does it treat

treat CMV
highly nephrotoxic

21

what agents are used to treat Hep B virus infection

Adefovir, Lamivudine, entecavir, telbivudine, tenofovir
interferon alfa

22

What are the adverse effects with Entecavir

dizziness and fatigue

23

what are the adverse effects of interferon for HVC infection

flu-like syndrome
H/A, myalgia, arthralgias, fatigue, malaise, fever, chills,
improves as treatment continues

24

what are the special considerations with interferons for HVC

contraindication to therapy
hepatic deompensation
autoimmune disease
history of arrhythmia
pregnancy

25

what are the adverse effects with ribavirin

used for HCV
hemolytic anemia
teratogenic
can't handle cansules if prego.

26

what are the special consideration with sofosbuvir

Used for HVC
$1,000 per tab
pan genotypic activity
make it possible to treat some pts with out interferon

27

how is simeprivir taken
what are special consideration of simeprevir

used for HCV
with food
assessment of Q80K mutation
drug interactions

28

what is the best method of routine prevention

inactivated influenza vaccine

29

what are the adverse effects with amantadine

CNS tox increase with elderly

30

what amantadine use to treat now

no longer used to treat influenza prophylaxis
used to treat parkinsons disease and drug induced EPS

31

Rimantadine adverse effects

less CNS adverse effects

32

what can actually happen to disinfectant and antispectic

they may become contaminated with spore or bacteria and transmit infection