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Flashcards in Antivirals Deck (27)
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1

Give 3 complications from varicella infection

CMV
Congenital limb anomalies (1st. 2nd trimester)
MRSA infection superimposed
Viral Pneumonia

2

Give the antiviral compound in Valaciclovir?

Acyclovir

3

Give the antiviral compound in Famciclovir?

Peninciclovir

4

Give the antiviral compound in Valganciclovir?

Valganciclovir

5

What enzyme is responsible for phosphorylation of acyclic nucleoside so that their antiviral activity for HSV and VZV?

Viral Thymidine Kinase

6

guanosine analogue antiviral drug that is also a prototype anti-herpes drug with good CSF penetration

Acyclovir

7

Mechanisma of action of acyclovir
a. Integrase inhibition
b. Protease Inhibition
c. DNA chain terminator
d.NOTA

C

8

True about acyclovir EXCEPT
a. Exhibits low activity for Cytomegalovirus
b. Triphosphate form is the active drug
c. Needed in children with varicella lesions
d. Safe for pregnant women

C

9

True about acyclovir EXCEPT
a. IV acyclovir is for HSV and VZV
b. Oral acyclovir has low availability
c. Topical acyclovir is used for immunocompromised hosts with HSV infection
d. NOTA

D

10

What is common among TK-negative mutants, TK-partial mutants, TK altered mutants and DNA pol mutants?

Acyclovir resistant

11

L-valyl ester of acyclovir

Valacyclovir

12

[Class] Tenofivir

Nucleoside Reverse Transcriptase Inhibitor (NRTI)

13

[Class] Efavirenz

Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI)

14

[Class] Atazanavir

Protease Inhibitor

15

[Class] Maraviroc

CCR5 Inhibitor

16

[Class] Raltegravir

Integrase Inhibitors

17

[Class] Emtricitabine

NRTI

18

[Class] Encuvirtide

Fusion inhibitor

19

[Class] Zidovudine

NRTI

20

[Class] Lamivudine

NRTI

21

[Class] Nevirapine

NNRTI

22

[Class] Rotanivir

Protease inhibitor

23

Adverse effects of NRTI

LDH
Lactic acidosis
Dyslipidemia
Hepatic steatosis

24

Additional adverse reactions for Zidovudine

MN
Macrocytic anemia
Neutropenia

25

Contraindications for Zidovudine

Concurrent stvudine and myelosupressive agnets

26

Differentiate MOA of NRTI and NNRTI

reverse transcriptase inhibition by NRTI is via competition while NNRTI inhibits reverse transcriptase via non-competitive inhibition

27

What is the most recommended NNRTI?

Nevirapine