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Term III: Pharmacology > Antivirals > Flashcards

Antivirals Flashcards

1
Q

Hepatitis B - DNA or RNA virus

A

DNA

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2
Q

Hepatitis C - DNA or RNA virus

A

RNA

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3
Q

What is tropism?

A

Preference of viruses for certain host cells - Recognition by viral surface proteins of specific host cell surface proteins

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4
Q

What are the three basic approaches to treating viral diseases?

A
  1. Vaccination
  2. Chemo
  3. Stimulation of natural resistance
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5
Q

Amantadine

A

Anti-viral

Inhibits proton pump/acidification of endosome, inhibiting viral uncoating

Influenza

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6
Q

Oseltamivir (Tamifu)

A

Anti-viral
Inhibits budding & release

Take orally

Prophylactic treatment of influenza

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7
Q

Zanamivir (Relenza)

A

Anti-viral
Inhibits budding & release

Inhaled or intranasal

Prophylactic treatment of influenza

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8
Q

What are interferons?

A

Host-encoded proteins that defend against viruses by interfering with their ability to infect and replicate

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9
Q

Enfuviritide

A

Anti-viral
Entry/fusion inhibitor, blocks CD4 binding to HIV gp120

HIV

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10
Q

Efavirenz

A

NNRTI (non-nucleoside) - irreversibly inhibits RT

HIV

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11
Q

**gravir - Raltegravir

A

Anti-viral
Integrase inhibitors

HIV

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12
Q

**navir - Indinavir

A

Anti-viral
Protease inhibitors

HIV

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13
Q 
Post-exposure prophylactic (PEP) treatment is recommended for accidental infection by HIV. What is recommended duration?
A. One week
B. Two weeks
C. Four weeks
D. One year
E. Remainder of one's life
A

C

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14
Q

DNA or RNA virus? Pox

A

DNA

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15
Q

DNA or RNA virus? Polyoma

A

DNA

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16
Q

DNA or RNA virus? Polio

A

RNA

17
Q

DNA or RNA virus? Rabies

A

RNA

18
Q

DNA or RNA virus? SARS

A

RNA

19
Q

DNA or RNA virus? Ebola

A

RNA

20
Q

T or F. Enveloped viruses are MORE effective.

A

False

21
Q

DNA or RNA virus? Influenza

A

RNA

22
Q

Zidovudine (AZT/Retrovir)

A

Anti-viral

NRTI (nucleotide inhibitor of RT) - binds active site of polymerase, mimics nucleotides, and gets incorporated into RNA/DNA chain, preventing elongation

HIV

23
Q

Acyclovir

A

Anti-viral

NRTI (nucleotide inhibitor of RT) - binds active site of polymerase, mimics nucleotides, and gets incorporated into RNA/DNA chain, preventing elongation

Herpes

Term III: Pharmacology (19 decks)

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