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Block 4 > Antivirals > Flashcards

Antivirals Flashcards

(57 cards)

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1
Q

acyclovir indication

A

HSV 1/2; VZV shingles/chickenpox; ocular herpes

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2
Q

valacyclovir indication

A

herpes virus

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3
Q

famiciclovir indication

A

herpes virus

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4
Q

trifluridine indication

A

ocular herpes, HSV1/2

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5
Q

vidarabine indication

A

acute keratoconjunctivitis, recurrent epithelial keratitis HSV 1/2

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6
Q

brivudine indication

A

ocular herpes

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7
Q

ganciclovir indication

A

ocular herpes; CMV infections, lungs, eyes, GI; prophylactic for organ transplants; end-stage HIV-AIDs

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8
Q

valganciclovir indication

A

CMV

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9
Q

cidofovir indication

A

CMV retinitis in AIDs pts only

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10
Q

foscarnet indication

A

CMV retinitis in AIDs pt, acyclovir resistant mucocutaneous HSV

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11
Q

fomivirsen indication

A

CMV retinitis when no response to other drugs

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12
Q

entecavir indication

A

Hep B (more effective)

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13
Q

tenofovir indication

A

Hep B (more effective); HIV

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14
Q

lamivudine indication

A

Hep B (less effective)

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15
Q

adefovir indication

A

Hep B (less effective)

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16
Q

simeprevir indication

A

Hep C

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17
Q

sofosbuvir indication

A

Hep C

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18
Q

ledipasvir indication

A

Hep C

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19
Q

ombitasvir indication

A

Hep C

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20
Q

PEG -IFN indication

A

Hep C

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21
Q

Ribavarin indication

A

Hep C

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22
Q

Amantadine indication

A

influenza A, prophylaxis

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23
Q

rimantadine indication

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A

influenza A, prophylaxis

24
Q

Oseltamvir indication

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A

influenza A or B, prophylaxis

25
Zanamivir indication
influenza A or B, prophylaxis
26
acyclovir MOA
prodrug - (VE thymidine kinase) - acyclo- GMP to GTP 1, inhibits vDNA pol 2. chain termination via lack of 3' OH group
27
valacyclovir MOA
prodrug of acyclovir, ester cleaved
28
famiciclovir MOA
prodrug of penciclovir ( penciclovir is topical only)
29
trifluridine MOA
inhibits vDNA synthesis
30
vidarabine MOA
inhibits vDNA synthesis
31
ganciclovir MOA
GCV - (VE deoxyguanosine kinase) - mono -di- tri 1. inhibit vDNA pol 2. chain termination
32
valganciclovir MOA
prodrug of ganciclovir
33
cidofovir MOA
cidofir diphosphate inside cells - inhibits vDNA polymerase
34
fomivirsen MOA
antisense drug, forms double helix with mRNA of CMV to block transmission
35
entecavir MOA
synthetic nucleoside analogue, prodrug - tri - 1. inhibits HBV RT 2. chain termination
36
tenofovir MOA
nucleotide analog RT inhibitor, chain terminator via HBV RT
37
lamivudine MOA
synthetic nucleoside analogue, prodrug - tri - chain termination via HBV RT
38
simeprevir MOA
HCV protease inhibitor
39
sofosbuvir MOA
HCV polymerase inhibitor
40
ledipasvir MOA
NS5A inhibitor
41
ombitasvir MOA
NS5A inhibitor
42
Amantadine and rimantadine MOA
inhibit viral M2 proton channels, no uncoating, no replication
43
oseltamivir and zanamivir MOA
neuraminidase inhibitor, analog of sialic acid, prevent release of viral progeny from host
44
acyclovir ADRs
topical - burning; oral - N/D/HA/vertigo; IV - renal damage
45
acyclovir contraindications
coadmin with other nephrotoxic drugs
46
trifluridine ADRs
burning, stinging, edema of eyelid
47
vidarabine ADRs
burning, stinging
48
ganciclovir ADRs
granulocytopenia (correct with G-CSFs) and thrombocytopenia via inhibition of human DNA polymerase
49
gancicolvir contraindications
pregnancy; coadmin with zidovudine
50
foscarnet ADRs
nephrotoxic
51
fomivirsen ADRs
ocular inflammation (corrected with glucocorticoids)
52
tenofovir ADRs
weak inhibition of mammalian DNA polymerase
53
PEG-IFN ADRs
flu like sx, depression
54
Ribivarin ADRs
hemolytic anemia
55
Ribivarin contraindication
pregnancy
56
Amantadine and Rimantadine ADRs
usually well tolerated, CNS effects, dizzy, nervousness
57
zanamivir contraindications
asthma, COPD

Block 4 (1 decks)

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