Antivirals

Question 1

Blocks viral Na synthesis; requires 3 phosphorylation steps
1st: thymidine kinase
2nd & 3rd: in host

Selectively activated by infected cells only

Answer 1

Acyclovir

Question 2

Admin with these drugs and Acyclovir will decrease drug clearance and increase drug exposure

Answer 2

Probenecid and Cimetdine

Question 3

Modestly beneficial for recurrent HSV1 infxn
Decrease duration of sx for 1st episode of HSV2
Mostly beneficial if tx is begun w/in 24 hr after onset of rash for VZV infxn

Answer 3

Acyclovir

Question 4

More potent than acyclovir; given BID

Answer 4

Valacyclovir

Question 5

Inhibits viral DNa pol -> terminated DNaA elongation

Answer 5

Gancyclovir

Question 6

Reduces risk of Kaposi in AIDS px due to activity against HHV8

Answer 6

Gancyclovir

Question 7

L-valyl prodrug of ganciclovir; as effective as gancyclovir for CMV retinitis tx

Answer 7

Valgancyclovir

Question 8

Inorganic pyrophosphate analog; does not require phosphorylation to inhibit viral dna pol

Answer 8

Foscarnet

Question 9

Effective for acyclovir resistant HSV & VZV

Answer 9

Foscarnet

Question 10

Phosphorylation is independent of viral enzymes

Answer 10

Cidofovur

Question 11

IV must be admin with high dose probenecid; AE: dose-dep proximal tubular nephrotoxicity

Answer 11

Cidofovir

Question 12

Examples of NRTIs

Answer 12

Abacavir, Tenofovir, -sine, -dine, -bine (Didanosine, Emtricitabine, Lamivudine, Stavudine, Zidovudine)

Question 13

NNRTIs

Answer 13

-vir- in the middle (Delavirdine, Efavirenz, Etravirine, Nevirapine, Rilpivirine)

Question 14

Protease inhibitors

Answer 14

-navir at the end (Atazanavir, Darunavir, Fosamprenavir, …)

Question 15

Entry inhibitor that binds to gp41 preventing conformational changes

Answer 15

Enfuvirtide

Question 16

Entry inhib that binds to host CCR5

Answer 16

Maraviroc

Question 17

Integrase strand transfer inhib (INSTIs)

Answer 17

-gravir at the end (INSTI-gravir: Dolutegravir, Elvitegravir, Raltegravir)

Question 18

NRTI for pregnancy

Answer 18

Abacavir, Tenofovir, Zidovudine, Emtricitabine, Lamivudine

Question 19

Only NNRTI for pregnancy

Answer 19

Nevirapine

Question 20

Protease inhib for pregnancy

Answer 20

Lopinavir/ritonavir, Atazanavir, Darunavir, Saquinavir (PRI LADS = PRIgnant LADieS)

Question 21

Antihepattis agent that functions by induction of intracellular signals ff binding to specific cell membrane receptors

Answer 21

Interferon alfa

Question 22

Injectable tx for HBV and HCV

Answer 22

iFN-a

Question 23

MOA of olsetamivir & zanamivir (Zana Ol - mivir) (antiinfluenza)

Answer 23

Neuraminidase inhib (interfere with release of viral progenies from host-> halt infection)

Question 24

Tx for both influenza A & B

Answer 24

Olsetamivir & Zanamivir

Question 25

MOA of amantidine & rimatadine

Answer 25

Block M2 PBlock M2 proton pump ion channel; inhibit uncoating of viral rna

Question 26

For active influenza a only

Answer 26

Amantidine & rimatadine