anxiety Flashcards

from Abrar's Kaplan Summaries. (45 cards)

1
Q

what is normal anxiety?

A

diffuse, unpleasant, vague sense of apprehension, often accompanied by
autonomic symptoms such as headache, perspiration, palpitations, tightness in the
chest, mild stomach discomfort, & restlessness, indicated by an inability to sit or
stand still for long.

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2
Q

Fear versus Anxiety

A

Fear is a response to a known, external, definite, or nonconflictual threat
Anxiety is a response to a threat that is unknown, internal, vague, or conflictual.

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3
Q

Is Anxiety Adaptive?

A

short answer: yes.
abrar kaplan:
“Anxiety can be conceptualized as a normal and adaptive response that has lifesaving qualities and warns of threats
 It prompts a person to take the necessary steps to prevent the threat or to lessen its consequences.
 This preparation is accompanied by increased somatic and autonomic activity controlled by the interaction of the
sympathetic and parasympathetic nervous systems. “

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4
Q

stress and anxiety (just read to rmbr, no real question here)

A

from kaplan, not abrar:
“ Whether an event is perceived as stressful depends on the nature of the event and on the person’s resources, psychological defenses, and
coping mechanisms. All involve the ego, a collective abstraction for the process by which a person perceives, thinks, and acts on external
events or internal drives. A person whose ego is functioning properly is in adaptive balance with both external and internal worlds; if the
ego is not functioning properly and the resulting imbalance continues sufficiently long, the person experiences chronic anxiety.
Whether the imbalance is external, between the pressures of the outside world and the person’s ego, or internal, between the person’s
impulses (e.g., aggressive, sexual, and dependent impulses) and conscience, the imbalance produces a con ict. Whereas externally caused
con icts are usually interpersonal, those that are internally caused are intrapsychic or intrapersonal. A combination of the two is possible, as
in the case of employees whose excessively demanding and critical boss provokes impulses that they must control for fear of losing their
jobs. Interpersonal and intrapsychic con icts, in fact, are usually intertwined. Because human beings are social, their main con icts are
usually with other persons”

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5
Q

symptoms of anxiety?

A

Anxiety experience has 2 components, the awareness of physiological sensations & of being nervous or frightened.
it produces confusion & distortions of perception, (of time, space & of persons and the meanings of events).
can interfere with learning by lowering concentration, reducing recall, & impairing the ability to make associations.

head: dizziness, hyperhydrosis, pupillary mydriasis
Heart: palpitations, tachycardia, syncope
extremites: tingling, tremors, restlessness, hyperreflexia,
GIT: upset stomach “butterflies” diarrhea, urinary freq/urgency,

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6
Q

epidemiology of anxiety

A
  • one in four
  • 17.7% prevalence
  • women more
  • higher socioeconomic less
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7
Q

what are the three major schools of psychological theory for anxiety?

A

Psychoanalytic
behavioral
existential

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8
Q

what is the psychoanalytic theory for anxiety?

A

Freud redefined anxiety as a signal of the presence of danger in the unconscious.
 Anxiety was viewed as the result of psychic conflict between unconscious sexual or aggressive wishes and
corresponding threats from the superego or external reality.
 In response to this signal, the ego mobilized defense mechanisms to prevent unacceptable thoughts and feelings
from emerging into conscious awareness.
 The role of the amygdala, which sub serves the fear response without any reference to conscious memory and
substantiates Freud’s concept of an unconscious memory system for anxiety responses. From a psychodynamic perspective, the goal of therapy is not necessary to eliminate all anxiety but to increase
anxiety tolerance-that is, the capacity to experience anxiety-and use it as a signal to investigate the underlying
conflict
 At the most mature level, superego anxiety is related to guilt feelings about not living up to internalized standards of
moral behavior derived from the parents.
 Often, a psychodynamic interview can elucidate the principal level of anxiety with which a patient is dealing. Some
anxiety is obviously related to multiple conflicts at various developmental levels.

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9
Q

what is the behavioral theory for anxiety?

A

 anxiety is a conditioned response to a specific environmental stimulus.
 In the social learning model, a child may develop anxiety response by imitating the anxiety in the environment

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10
Q

what is the existential theory of anxiety?

A

It provides models for generalized anxiety, in which no specific identifiable stimulus for chronic anxious feeling.
 The central concept of existential theory is that person experience feelings of living in a purposeless universe.
 Anxiety is their response to the perceived void in existence and meaning.

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11
Q

autonomic nervous system in patients with anxiety?

A

The autonomic nervous systems of some pt with anxiety disorder exhibit increased sympathetic tone, adapt slowly to
repeated stimuli, and respond excessively to moderate stimuli.

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12
Q

The three major neurotransmitters associated with anxiety are

A

norepinephrine (NE), serotonin, & GABA.

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13
Q

Chronic symptoms experienced by anxious pt are characteristic of

A

increased noradrenergic function.

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14
Q

The cell bodies of the noradrenergic system are localized to

A

the locus ceruleus in the rostral pons

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15
Q

The cell bodies of the noradrenergic system are localized to the locus ceruleus in the rostral pons, and they project
their axons to

A

the cerebral cortex, the limbic system, the brainstem, and the spinal cord.

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16
Q

Experiments demonstrated that stimulation of …? produces fear response in the animals and that
ablation of the same area inhibits or completely blocks the ability of the animals to form a fear response.

A

locus ceruleus

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17
Q

what can provoke frequent and severe panic attacks in patients with panic disorder?

A

ß-adrenergic receptor agonists & α adrenergic receptor antagonists

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18
Q

what receptor does the drug yohimbine act on?

A

α adrenergic receptor antagonist

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19
Q

what receptor does the drug clonidine act on?

A

α2-receptor agonist

20
Q

does yohimbine increase or decrease anxiety?

21
Q

does clonidine increase or decrease anxiety?

22
Q

what is the noradrenergic metabolite called?

A

3-methoxy-4-hydroxyphenylglycol (MHPG).

23
Q

which patient have increased levels of CSF or Urinary 3-methoxy-4-hydrophenylglycol?

A

patients with anxiety disorders, particularly panic disorder

24
Q

Cortisol increased ? , ?, ?, & ?; inhibition of the ? and
?; and ?.

A

Cortisol increased arousal, vigilance, focused attention, & memory formation; inhibition of the growth and
reproductive system; and containment of the immune response.

25
Excessive & sustained cortisol secretion lead to ?, ?, ?, ?, ?, ?, ?and ?.
Excessive & sustained cortisol secretion lead to hypertension, osteoporosis, immunosuppression, insulin resistance, dyslipidemia, dyscoagulation, atherosclerosis and cardiovascular disease.
26
In patients with panic disorder, ? responses to corticotropin-releasing factor (CRF) have been reported in some studies
In patients with panic disorder, blunted adreno-corticoid hormone (ACTH) responses to corticotropin-releasing factor (CRF) have been reported in some studies
27
Hypothalamic levels of CRH are increased by stress, resulting in activation of the HPA axis and increased release of ? and ?.
Hypothalamic levels of CRH are increased by stress, resulting in activation of the HPA axis and increased release of cortisol and de-hydro-epi-androsterone (DHEA).
28
stress ↑(5-HT) turnover in the ?, ?, ?, and ?.
stress ↑(5-HT) turnover in the prefrontal cortex, nucleus accumbens, amygdala, and lateral hypothalamus.
29
(5-HT1A agonist) used in the treatment on anxiety?
buspirone
30
The cell bodies of serotonergic neurons are located in the ? in the ? and project to the ?, ?, and the ?.
The cell bodies of serotonergic neurons are located in the raphe nuclei in the rostral brainstem and project to the cerebral cortex, the limbic system (especially, the amygdala and the hippocampus), and the hypothalamus.
31
Serotonergic drugs like ?, ?anxiety in pt with anxiety disorders
Serotonergic drugs like metachlorophenylpiperazine (mCPP) & fenfluramine, ↑anxiety in pt with anxiety disorders
32
serotonergic hallucinogens and stimulants like ? )—are associated with the development of ?
serotonergic hallucinogens and stimulants-like (LSD) & (MDMA) )—are associated with the development of both acute and chronic anxiety disorders in persons who use these drugs
33
benzodiazepines enhance the activity of ?
benzodiazepines enhance the activity of GABA at the GABA type A (GABAA) receptor
34
low-potency benzo are effective for ? & high potency (?, ?) are effective in ?
low-potency benzo are effective for GAD & high potency (alprazolam, clonazepam) are effective in panic disorder
35
symptoms of anxiety disorders are induced when a benzodiazepine inverse agonist, ?, is administered
symptoms of anxiety disorders are induced when a benzodiazepine inverse agonist, β-carboline-3-carboxylic acid (BCCE), is administered
36
benzodiazepine antagonist (?), causes frequent severe panic attacks in patients with panic disorder.
benzodiazepine antagonist (flumazenil), causes frequent severe panic attacks in patients with panic disorder.
37
APLYSIA
neurotransmitter model for anxiety disorders is based on the study of Aplysia californica by Nobel Prize winner Eric Kandel, M.D. (sea snail that reacts to danger by moving away, withdrawing into its shell, and decreasing its feeding behavior →classically conditioned, so that the snail responds to a neutral stimulus as if it were a dangerous stimulus.)
38
? is a highly conserved 36-amino acid peptide
NEUROPEPTIDE Y (NPY)
39
Evidence suggesting the involvement of the amygdala in the anxiolytic effects of ? is robust.
NEUROPEPTIDE Y (NPY)
40
NPY has counterregulatory effects on ? and ? systems at brain sites that are important in the expression of ?
NPY has counterregulatory effects on corticotropin-releasing hormone (CRH) and LC-NE systems at brain sites that are important in the expression of anxiety, fear, and depression
41
studies in special operations soldiers under extreme training stress indicate that high NPY levels are associated with ?
better performance.
42
peptide contains 30 amino acids, involved in learning, memory, food intake, pain & neuroendocrine control, cardiovascular regulation, & anxiety.
galanin
43
galanin system originating in the ? innervates ? & ? structures
galanin system originating in the LC innervates forebrain & midbrain structures (hippocampus, hypothalamus, amygdala, & prefrontal cortex).
44
? and ? may be novel targets for antianxiety drug development
Galanin and NPY receptor agonists may be novel targets for antianxiety drug development
45
brain imaging in anxiety showed?
- some increase in the size of cerebral ventricles - in one MRI study specific defect in the right temporal lobe was noted in patients with panic disorder - abnormal findings in the right hemisphere but not the left hemisphere - abnormalities in the frontal cortex; the occipital and temporal areas - in a study of panic disorder abnormalities in the para-hippocampal gyrus