Applied Pharm - Anti-Depressents

Question 1

Name 2 MAOIs

Answer 1

Phenelxine and Tranylcypromine

Question 2

What are the adverse effects of MAOIs? (6)

Answer 2

Hypertensive crisis, Cytochrome P450 inhibition, weight gain, oedema, sedation, sexual dysfunction

Question 3

What does MAOI stand for?

Answer 3

Monoamine oxidase inhibitor

Question 4

Name 2 5HT releasers

Answer 4

Fenfluramine

MDMA

Question 5

What do 5HT1A - F receptors do?

Answer 5

Decrease cAMP

Question 6

What do 5HT4,6, 7, 5A and 5b receptors do?

Answer 6

Increase cAMP

Question 7

What do 5HT2A - C receptors do?

Answer 7

increase inositol, phosphates and calcium

Question 8

Name 4 tricyclic anti-depressants

Answer 8

Desipramine
Imipramine
Amitryptiline
Doxepen

Question 9

Name 4 SSRIs

Answer 9

Fluoxetin
Sertraline
Paroxetine
Citalopram

Question 10

What are the adverse effects of tricycle anti-d’s? (6)

Answer 10

Weight gain, sedation, sexual dysfunction, cytochrome P450 inhibition, dry mouth, dizziness

Question 11

What are the adverse effects of SSRIs? (3)

Answer 11

Dependence, withdrawal, sexual dysfunction

Question 12

What are the contraindications for tricyclic anti-d’s? (2)

Answer 12

MI

Coronary artery disease

Question 13

What drugs should be avoided when using tricyclic anti-d’s?

Answer 13

Anti-histamines, CNS depressants

Question 14

What are the contraindications for SSRIs?

Answer 14

Previous mania or anxiety

Question 15

What drugs should be avoided when using SSRIs?

Answer 15

MAOIs, warfarin

Question 16

What are the contraindications for MAOIs? (4)

Answer 16

Renal/hepatic dysfunction, hypertension, pregnancy and lactation

Question 17

Name 2 next generation anti-d’s

Answer 17

Bupropion

Venlafaxine

Question 18

Name 4 mood stabilising drugs

Answer 18

Lithium carbonate
Lithium citrate
Valproate
Carbamazepine

Question 19

What are the contraindications for mood stabilisers? (4)

Answer 19

Renal dysfunction
Leukaemia
Dehydration
Sodium depletion

Question 20

What adverse effects do mood stabilisers have? (7)

Answer 20

Headache, dizziness, confusion, hair loss, oedema, arrhythmia, withdrawal

Question 21

What drugs should be avoided with mood stabilisers? (3)

Answer 21

NSAIDS, anti-psychotics, diuretics

Question 22

Name 4 anti-psychotics

Answer 22

Chlorpromazine
Loxapine
Fluphenazine
Haloperidol

Question 23

What are the contraindications for anti-psychotics? (7)

Answer 23

CVD, bone marrow depression, renal/liver/thyroid dysfunction, Parkinson’s

Question 24

WHat are the adverse effects of anti-psychotics? (5)

Answer 24

Parkinsonism, sedation, hypotension, impaired thermoregulation, tardive dyskinesia

Question 25

What drugs should be avoided with anti-psychotics? (4)

Answer 25

CNS depressants, anti-convulsants, hypertension meds and antacids

Question 26

Name 4 sedative hypnotics

Answer 26

Thiopental Secobarbital Zolpidem Phenobarbital

Question 27

What adverse effects doe sedative hypnotics have? (4)

Answer 27

Drowsiness, hangover, tolerance, dependence

Question 28

What contraindications for sedative hypnotics? (3)

Answer 28

Under 18s, pregnancy and lactation

Question 29

What drugs should be avoided with sedative hypnotics?

Answer 29

CNS depressants

Question 30

Name a non-benzo anxiolytic

Answer 30

Buspirone

Question 31

What are the adverse effects of buspirone? (6)

Answer 31

dizziness, headaches, insomnia, dry mouth, blurred vision, palpitations

Question 32

What drugs should be avoided with Buspirone?

Answer 32

CNS depressants, MAOIs

Question 33

Name 4 benzo anxiolytics

Answer 33

Diazepam Alprazolam Temazepam Lorazepam

Question 34

Adverse affects of benzos? (6)

Answer 34

Over sedation, headache, dry mouth, blurred vision, memory loss, hypotension

Question 35

contraindications for benzos? (4)

Answer 35

Renal/liver dysfunction, pregnancy, lactation

Question 36

Name 4 atypical anti-psychotics

Answer 36

Clozapine Amisulpride Risperidone Olanzepine

Question 37

What are the adverse effects of atypical anti-psychotics? (12!)

Answer 37

headache, blurred vision, photo-sensitivity, insomnia, nervosness, dizziness, GI distress, weight gain, ulcers, glaucoma, retention, liver dysfunction

Question 38

Dugs to avoid with atypical anti-psychotics?

Answer 38

CNS depressants, anti-hypertensives