Article 6 Flashcards
what is proprioception and why is it important in our sensory perception and basic motor functions?
sense of body and limb position, vital for both unconscious and conscious sensations and basic motor functions
where are the proprioceptive sensory neurons found in mammals
dorsal root ganglia, connect to two distinct mechanoreceptors in skeletal muscle: muscle spindles and golgi tendon organs
what are TRPN/NompC and DEG/ENaC channells?
are ion channel families involved in mechanotransduction for proprioception in organisms like drosophila and c elegans
what role do sodium and calcium ions play in mechanically activated currents in proprioceptive neurons?
neurons are mediated by sodium ions, w minor contribution from calcium ions.
what are piezo channels
nonselective cation channels involved in mechanotransduction and volume signaling
how are piezo channels involved in mechanotransduction and sensory functions in mice?
piezo1 is critical for vascular remodeling and red blood cell volume regulation, while piezo 2 is expressed in sensory neurons and serves as mechanotransductor for low threshold mechanoreceptors in murine skin
What is the significance of parvalbumin (Pvalb)-expressing sensory neurons in the context of proprioception, and how do they relate to Piezo2 channels?
Parvalbumin-expressing sensory neurons are primarily responsible for proprioception in mammals. They exhibit nonselective cationic currents consistent with Piezo2 channels, leading researchers to explore whether Piezo2 is involved in mammalian proprioception.
what is the goal of this study
to identify the molecular mechanisms underlying proprioception in mammals, with a specific focus on the potential involvement of Piezo2 channels
what are the primary ions that mediate mechanically activated currents and how is this assertion supported?
Na and Ca. based on stretch induced extracellular voltage recordings of muscle spindle afferents
