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PMOC LAB/LEC MIDTERM > Aspirin/ Acetone/ Acetanilide > Flashcards

Aspirin/ Acetone/ Acetanilide Flashcards

(69 cards)

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1
Q

IUPAC name of Aspirin?

A

2-acetoxybenzoic acid

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2
Q

Chemical formula of Aspirin?

A

C9H8O4

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3
Q

Give the synonyms of Aspirin

A

Acetyl salicylic acid
Acidium salicylicum
o-acetylsalicylic acid
polypiryna
salicylic acidacetate

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4
Q

Chemical Synthesis of Aspirin?

A

Ester Formation/ Esterification

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5
Q

Synthesis of Aspirin?

A

Salicylic Acid (HO-C6H4-COOH) + Acetic anhydride (CH3C=O-O-C=OCH3) –(H2SO4)——> Acetyl salicylic acid (CH3C=OOC6H4-COOH) + Acetic Acid (OHC=OCH3)

Salicylic Acid (HO-C6H4-COOH) + Acetyl chloride (CH3-C=O-Cl) —-(pyridine)—> Acetyl salicylic acid (CH3C=OOC6H4-COOH) + hydrochloric acid (HCl)

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6
Q

Physical properties of Aspirin?

A

Colorless/ white crystalline powder
odorless
Density:1.40 g/cm3
MP: 135 C/ 275 F
BP: 140 C/ 284 F
Solubility in H2O: 3mg/ml [20 C]

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7
Q

Acid Hydrolysis positive result?

A

violet

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8
Q

Base Hydrolysis positive result?

A

Clear/ colorless sol.

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9
Q

what reagent makes the enol CMPD turn violet?

A

FeCl/Ferric chloride

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10
Q

State the aspirin indications:

A

ANTI-PLATELET (40-80mg)
ANTI-INFLAMMATORY (45mg/kg)
ANALGESIC (325-650mg)
ANTIPYRETIC (325-650mg)

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11
Q

what receptor aspirin bind?

A

Arachidonic acid

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12
Q

Arachidonic Acid

A

promotes the repair and growth of skeletal muscle tissue via conversion to prostaglandin PGF2alpha during and following physical exercise

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13
Q

Release PGE2 GI mucosa for cytoprotection
INC mucus production
INC HC03
INC BLOOD FLOW

A

COX1

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14
Q

PGE2 + PGI2 => Kidney
INC GFR (filtration of kidney)
Retention of Na & H2O
roles in mediating inflammation

A

COX1 &COX2

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15
Q

PGI2 + TXA2
COX2= PGI2
promotes Cardiovascular
vasodilation
INC platelet aggregation

A

COX1 + COX2

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16
Q

Aspirin inhibits

A

COX 1, COX 2, TXA2

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17
Q

Active peptic ulcer
haemostatic disorder
hypersensitivity
asthma
kidney disease (exacerbate the condition)
Hyperuricemia or gout
Hemolytic anemia
Dengue fever
Children or adolescents w/ viral interfection

A

Aspirin contraindication

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18
Q

viral infection in the children then take an aspirin to relief the fever can cause _______

A

reye’s syndrome

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19
Q

acute ingestion of 150-200 mg/kg ASA will produce___

A

Mild intoxication

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20
Q

acute ingestion of 300-500 mg/kg ASA will produce___

A

severe intoxication

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21
Q

ingestion of more than 100 mg/kg/day, 2 or more days of ASA will produce___

A

chronic intoxication

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22
Q

Vomiting after ingestion
hyperpnea
Tinnitus & Lethargy
Mixed respiratory Alkalemia
metabolic Acidosis

A

acute toxicity of ASA

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23
Q

Rapid and shallow breathing

A

Hyperpnea

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24
Q

nonspecific confusion
dehydration and metabolic acidosis are attributed to sepsis
Pneumonia
Gastroenteritis

A

Chronic Toxicity of Aspirin

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25
Treatment for ASA toxicity
Activated charcoal NaHCO3(Sodium Bicarbonate) Hemodialysis
26
Why aspirin is a better pain reliever than salicylic acid?
ASA is less irritating to the stomach and not bitter
27
Why do people without H/A or pain use ASA regularly as their maintenance drug?
ASA inb. COX1 => no TXA2 that promotes platelet aggregation use for stroke and heart attack
28
why ASA cause methemoglobinemia?
ASA convert ferric to ferrous. Ferric is the responsible for O2 in RBC
29
IUPAC name of Acetanilide?
N-phenylethanamide
30
Chemical Formula of Acetanilide
C8H9NO
31
Synonym of Acetanilide
acetylaminobenzene CAN Antifelorin acetylaniline N-phenylethanamide
32
what is Antifelorin use and ADR
analgesic and antipyretic ADR: cyanosis (blue skin)
33
metabolic pathway of Antifelorin
phenolic metabolisim
34
Synthesis of Acetanilide?
aniline (C6H5-N Acetanilide(C6H5-NH-C=O- CH3) + HCI aniline (C6H5-N Acetanilide(C6H5-NH-C=O- CH3)+ Acetic Acid (OHC=OCH3)
35
Process of synthesis of acetanilide ?
Acetylation
36
what process makes the acetanilide purify
Crystallizations
37
A positive result of acid hydrolysis of acetanilide
crystal formation (aniline)
38
A positive result of bromination of acetanilide
white ppt upper and lower part/ clear in the middle
39
A positive result of bromination of Aniline
yellow slimy substance at the middle
40
acetanilide forms______ in bromination
mono brominates (as major product) 4-bromo acetanilide
41
aniline forms______ in bromination
tri-mono brominates (as major product) tribromoaniline
42
Synonyms of acetone
2- propanone Dimethyl ketone Propanone beta- ketopropan Dimentyl formaldehyde
43
simplest ketone
acetone
44
physical appearance of acetone
colorless and flammable
45
Bolling point of acetone
133 F/ 56.2 C
46
acetone is normally present in ____ and ______
Blood , urine
47
______produce it in larger amounts
Diabetic people
48
people on a ________ will have more acetone in their body
Low fat diet
49
Use of acetone
solvent denaturant in alcohol defatting prior to chemexfoliation
50
A substance attracted to by ______(transmit the parasitic protozoan known to produce the often fatal disease called_______) including carbon dioxide and octenol
tseste files, sleeping sickness
51
acetone exhibit only _____in normal use
slight toxicity
52
Cumen process is aka_____
Phenol processss or hock process
53
Propylene + water ==> 2-propanol 2-propanol + Oxygen ==> acetone what synthesis process is this?
wacker--Hoechst process
54
synthesis of ____ of Acetates
Dry distillation
55
Acetone- butanol- ethanol fermentation developed by _____with the aid of _____ bacteria.
Chaim Mweizman, Clostridium acetobutylicum
56
____ is no longer used due to small yields
Acetone- butanol- ethanol fermentation
57
tollen test result of acetone
negative clear
58
Bisulfite Addition result
white ppt
59
acetone functional group
carbonyl group
60
Methadone
potent analgesic
61
naloxone
opioid analgesic
62
Acetaphenone
sedative
63
ketone bodies present in urine
Ketonuria
64
acetone breath
ketoacidosis
65
Acetone is formed when body use____instead of glucose for energy. Acetone is broken down by ____ which oxidized via _____ to yield energy.
fat, acetyl coa, TCA cycle
66
Sodium nitroprusside and strong solution of ammonia water is a test for ?
presence of ketonuria
67
Sodium nitroprusside and strong solution of ammonia water positive result?
magenta ring form at the line of contact
68
Cynide nitropursside teste test aka
Brand test
69
brand test + result
red purple colour

PMOC LAB/LEC MIDTERM (2 decks)

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