Asthma And Copd

Question 0

What does Th2 do in asthma?

Answer 0

Helps B cells switch to IgE isotope

Question 1

What does IL 4 do in asthma?

Answer 1

Promote Th2

Enhance IgE switch

Question 2

What happens on a microscopic level for Reexposure to an antigen in asthma?

Answer 2

Dear halting of mast cells from the binding of IgE

Question 3

What is atopy?

Answer 3

Exaggerated tendency to form IgE to allergens

Increased eosinophils

Question 4

What does IgE beta chain do for asthma?

Answer 4

Increases affinity for FCe receptor on mast cells

Question 5

What does the TIM gene family do in asthma?

Answer 5

Regulates Th1 Th2 balance

Question 6

What is the hygiene hypothesis?

Answer 6

Since newborns more apt to form Th2, they need exposure to Th1 forming things like viral infections to generate a balance. This cannot be accomplished in a super hygienic environment and will cause asthma or other atopic events like eczema and allergic rhinitis

Question 7

What cytokines cause B cells to switch to IgE?

Answer 7

Low IL 12
High IL 4
IL 13

Question 8

What type of response is allergic asthma?

Answer 8

Type I precipitated by a previous Type IV response

Question 9

For asthma, what does a type IV response create?

Answer 9

Switch from IgG to IgE

Question 10

For asthma, what does a type I response create?

Answer 10

Mast cell de granulation

Question 11

Preformed mast cell mediators?

Answer 11

Histamines
Proteoglycans
Tryptase
Chymase

Question 12

What type of reaction do typeI hypersensitivity mediators induce?

Answer 12

Vasodilation
Brochoconstriction
Inflammation
Mucus secretion

Question 14

Full copd is due to what three things?

Answer 14

Environmental stimuli
Genetic susceptibility
Failure of immunoregulatory mechs

Question 15

What causes the inflammation in COPD?

Answer 15

ROS due to neutrophils and macrophages

CD8 T cells

Question 16

What is the danger hypothesis?

Answer 16

cells being damaged by exposures release danger signals that bind to toll like receptors
this leads to inflammation
act of neutrophils and macrophages which release proteolytic enzymes

Question 17

What T cell would down regulate the pathophys of COPD?

Answer 17

Treg

Question 18

What is the purpose of Tfh?

Answer 18

helps B cells make IgG and IgA

part of the possible autoimmunity aspect of the disease

Question 19

Overview of asthma?

Answer 19

reversible inflammation
extrinsic inciting antigen
CD4, Th2
IL4
Effectors-B cells, IgE, mast cells

Question 20

Overview of COPD?

Answer 20

irreversible inflammation
intrinsic inciting factor
CD4, Th1
IL 12
Effectors- CD8, macrophages/neutrophils

Question 21

What is the purpose of Th1?

Answer 21

incite cell mediated immunity and inflammatory cytokines

Question 22

What is the purpose of Th2?

Answer 22

evoke strong antibody response

Question 23

What 2 reactions are associated w/ asthma?

Answer 23

first a type Iv reaction to create IgE

then Type I reaction everytime an antigen is detected