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PHRM825 > Asthma and COPD Controller Medications > Flashcards

Asthma and COPD Controller Medications Flashcards

1
Q

beclomethasone drug class

A

inhaled corticosteroids (ICS)

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2
Q

beclomethasone brand name

A

QVAR

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3
Q

beclomethasone dosage form

A

RediHaler (MDI)

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4
Q

beclomethasone age groups

A

> = 5 years old

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5
Q

budesonide drug class

A

inhaled corticosteroids (ICS)

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6
Q

budesonide brand names

A

Pulmicort and Pulmicort Respules

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7
Q

Pulmicort dosage form

A

flexhaler

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8
Q

Pulmicort Respules dosage form

A

nebulizer solution

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9
Q

Pulmicort age groups

A

> = 5 years old

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10
Q

Pulmicort Respules age groups

A

0-11 year olds

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11
Q

Pulmicort Respules counseling tip

A

should use jet nebulizer and not be mixed with other nebulizer medications

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12
Q

ciclesonide drug class

A

inhaled corticosteroids (ICS)

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13
Q

ciclesonide brand name

A

Alvesco

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14
Q

ciclesonide dosage form

A

HFA

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15
Q

ciclesonide age groups

A

> = 6 years old

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16
Q

fluticasone propionate drug class

A

inhaled corticosteroids (ICS)

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17
Q

fluticasone propionate brand names

A

Flovent and ArmonAir Digihaler

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18
Q

Flovent dosage forms

A

HFA and DPI

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19
Q

ArmonAir Digihaler dosage form

A

aerosol powder inhaler (DPI)

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20
Q

Flovent age groups

A

all

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21
Q

ArmonAir Digihaler age group

A

> = 12 years old

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22
Q

fluticasone furoate drug class

A

inhaled corticosteroids (ICS)

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23
Q

fluticasone furoate brand name

A

Arnuity Ellipta

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24
Q

fluticasone furoate dosage form

A

ellipta

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25
fluticasone furoate age groups
>=5 years old
26
mometasone drug class
inhaled corticosteroids (ICS)
27
mometasone brand name
Asmanex
28
mometasone dosage forms
HFA and Twisthaler
29
mometasone age groups
>= 5 years old
30
inhaled corticosteroids adverse effects
-oral thrush (candidiasis) -cough -dysphonia
31
ICS counseling tips
-patients should rinse mouth and spit after use to prevent oral thrush -most effective long-term control therapy for asthma (improves quality of life, increases lung function, and reduces risk of exacerbations) -may increase risk of pneumonia in patients with COPD -titrate to lowest effective dose -high doses increase risk for systemic side effects
32
arformoterol tartrate drug class
long-acting beta agonist (LABA)
33
arformoterol tartrate brand name
Brovana
34
arformoterol tartrate dosage form
nebulizer solution
35
arformoterol tartrate age group
>=12 years old
36
arformoterol tartrate indication
COPD
37
formoterol drug class
long-acting beta agonist (LABA)
38
formoterol brand name
Perforomist
39
formoterol dosage form
nebulizer solution
40
formoterol age group
>=12 years old
41
formoterol indication
COPD only unless used in combination with ICS
42
indacaterol drug class
long-acting beta agonist (LABA)
43
indacaterol brand name
Arcapta Neohaler
44
indacaterol dosage form
neohaler
45
indacaterol age group
>= 12 years old
46
indacaterol indication
COPD
47
olodaterol drug class
long-acting beta agonist (LABA)
48
olodaterol brand name
Striverdi Respimat
49
olodaterol dosage form
respimat
50
olodaterol age group
>= 12 years old
51
olodaterol indication
COPD
52
salmeterol drug class
long-acting beta agonist (LABA)
53
salmeterol brand name
Serevent
54
salmeterol dosage form
diskus
55
salmeterol age groups
>= 4 years old
56
LABA adverse effects
-tachycardia -headache -tremor -hypokalemia
57
LABA boxed warnings
-increased risk of asthma-related death for all monotherapy (LABA should not be used alone for asthma management) -increasing hospitalizations in pediatric and adolescent patients
58
LABA counseling tips
-prolonged QT seen with intentional overdoses -not for acute symptoms -may be helpful for exercise-induced bronchospasm -formoterol and indacaterol capsules should not be taken orally
59
LABA pediatric consideration
most children <4 years old cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI
60
aclidinium drug class
long-acting antimuscarinic (LAMA)
61
aclidinium brand name
Turdorza Pressair
62
aclidinium dosage form
DPI
63
aclidinium age group
>= 12 years old
64
aclidinium indication
COPD
65
glycopyrrolate drug class
long-acting antimuscarinic (LAMA)
66
glycopyrrolate brand name
Seebri Neohaler
67
glycopyrrolate dosage forms
DPI and nebulization solution
68
glycopyrrolate age group
>=12 years old
69
glycopyrrolate indication
COPD
70
revefenacin drug class
long-acting antimuscarinic (LAMA)
71
revefenacin brand name
Yupelri
72
revefenacin dosage form
nebulization solution
73
revefenacin age group
>=12 years old
74
revefenacin indication
COPD
75
tiotropium drug class
long-acting antimuscarinic (LAMA)
76
tiotropium brand name
Spiriva
77
tiotropium dosage forms
HandiHaler and Respimat
78
Spiriva HandiHaler age group
>= 12 years old
79
Spiriva Respimat age groups
>= 6 years old
80
Spiriva HandiHaler indication
COPD
81
tiotropium counseling tip
approved for use in asthma as an add-on option for children >= 12 years old
82
umeclidinium drug class
long-acting antimuscarinic (LAMA)
83
umeclidinium brand name
Incruse Ellipta
84
umeclidinium dosage form
DPI
85
umeclidinium age group
>= 12 years old
86
umeclidinium indication
COPD
87
LAMA adverse effects
-dry mouth -dizziness -blurred vision -upper respiratory infections -paradoxical bronchospasms
88
fluticasone/salmeterol drug class
ICS/LABA combination
89
fluticasone/salmeterol brand names
Advair, AirDuo, and AirDuo Digihaler
90
Advair dosage forms
DPI and HFA MDI
91
Advair DPI age groups
>= 5 years old
92
Advair HFA MDI age group
>=12 years old
93
AirDuo and AirDuo Digihaler dosage form
Respiclick (DPI)
94
AirDuo and AirDuo Digihaler age group
>= 12 years old
95
budesonide/formoterol drug class
ICS/LABA combination
96
budesonide/formoterol brand name
Symbicort
97
budesonide/formoterol dosage form
HFA MDI
98
budesonide/formoterol age groups
>= 5 years old
99
mometasone/formoterol drug class
ICS/LABA combination
100
mometasone/formoterol brand name
Dulera
101
mometasone/formoterol dosage form
MDI
102
mometasone/formoterol age group
>= 12 years old
103
fluticasone/vilanterol drug class
ICS/LABA combination
104
fluticasone/vilanterol brand name
Breo Ellipta
105
fluticasone/vilanterol dosage form
DPI
106
fluticasone/vilanterol age group
>= 12 years old
107
ICS/LABA combination counseling tips
-recommend combination LABA with ICS in asthma because LABA should not be used as monotherapy -combination products were developed to create convenient packaging and assist with patient adherence
108
olodaterol/tiotropium drug class
LABA/LAMA combination
109
olodaterol/tiotropium brand name
Stiolto Respimat
110
olodaterol/tiotropium dosage form
Respimat
111
olodaterol/tiotropium age group
>= 12 years old
112
olodaterol/tiotropium indication
COPD
113
vilanterol/umeclidinium drug class
LABA/LAMA combination
114
vilanterol/umeclidinium brand name
Anoro Ellipta
115
vilanterol/umeclidinium dosage form
Ellipta
116
vilanterol/umeclidinium age group
>= 12 years old
117
vilanterol/umeclidinium indication
COPD
118
indacaterol/glycopyrronium drug class
LABA/LAMA combination
119
indacaterol/glycopyrronium brand name
Utibron Neohaler
120
indacaterol/glycopyrronium dosage form
Neohaler
121
indacaterol/glycopyrronium age group
>= 12 years old
122
indacaterol/glycopyrronium indication
COPD
123
formoterol/glycopyrronium drug class
LABA/LAMA combination
124
formoterol/glycopyrronium brand name
Bevespi Aerosphere
125
formoterol/glycopyrronium dosage form
Aerosphere
126
formoterol/glycopyrronium age group
>= 12 years old
127
formoterol/glycopyrronium indication
COPD
128
formoterol/aclidinium drug class
LABA/LAMA combination
129
formoterol/aclidinium brand name
Duaklir Pressair
130
formoterol/aclidinium dosage form
DPI
131
formoterol/aclidinium age group
>= 12 years old
132
formoterol/aclidinium indication
COPD
133
LABA/LAMA combination counseling tip
not indicated for treatment of acute deteriorations
134
fluticasone/umeclidinium/vilanterol drug class
LABA/LAMA/ICS combination
135
fluticasone/umeclidinium/vilanterol brand name
Trelegy Ellipta
136
fluticasone/umeclidinium/vilanterol dosage form
Ellipta
137
fluticasone/umeclidinium/vilanterol age group
>=12 years old
138
budesonide/glycopyrrolate/formoterol fumarate drug class
LABA/LAMA/ICS combination
139
budesonide/glycopyrrolate/formoterol fumarate brand name
Breztri Aerosphere
140
budesonide/glycopyrrolate/formoterol fumarate dosage form
Aerosphere
141
budesonide/glycopyrrolate/formoterol fumarate age group
>= 12 years old
142
budesonide/glycopyrrolate/formoterol fumarate indication
COPD
143
cromolyn drug class
mast cell stabilizer
144
cromolyn brand name
Intal
145
cromolyn dosage form
nebulizer solution
146
cromolyn age groups
all
147
mast cell stabilizer adverse effects
-high incidence of unpleasant taste in mouth (>10%) -rare cardiac arrhythmias -coughing -dyspnea -sore throat -nausea, vomiting, and diarrhea if absorbed systemically
148
mast cell stabilizer counseling tips
-less effective than low-dose ICS -prevents increase in bronchial hyperreactivity seen in allergy season
149
montelukast drug class
leukotriene modifiers
150
montelukast brand name
Singulair
151
montelukast dosage forms
tablets, chewable tablets, and granule packets
152
montelukast age groups
>= 1 year old
153
montelukast counseling tips
-minor substrate of CYP2C8/9 and 3A4 -not for acute relief of symptoms -boxed warning --> neuropsychiatric events
154
zafirlukast drug class
leukotriene modifiers
155
zafirlukast brand name
Accolate
156
zafirlukast dosage form
tablet
157
zafirlukast age groups
>= 5 years old
158
zafirlukast counseling tips
-take at least 1 hour before or 2 hours after meals -can increase INR -major substrate and minor inhibitor of CYP2C9
159
zileuton drug class
leukotriene modifiers
160
zileuton brand name
Zyflo CR
161
zileuton dosage forms
IR tablets and ER tablets
162
zileuton age group
>= 12 years old
163
zileuton counseling tips
-weak CYP1A2 inhibitor -take with food
164
leukotriene modifier adverse effects
-neuropsychiatric events (agitation, anxiety, abnormal dreams, hallucinations, depression, suicidal thinking) -Churg-Strauss syndrome (rare) -increased hepatic transaminases (zafirlukast and zileuton)
165
leukotriene modifier counseling tips
-less effective than low-dose ICS and ICS/LABA in asthma -have not been adequately trialed in COPD
166
theophylline drug class
methylxanthines
167
theophylline brand name
Theochron
168
theophylline dosage forms
ER 12 hour tablets, ER 24 hour tablets, ER 24 hour capsule, and liquid solution
169
theophylline indications
acute exacerbation and chronic management
170
methylxanthine adverse effects
-insomnia -gastrointestinal upset -hyperactivity -hypotension -tremor
171
methylxanthine dose-related toxicities
-tachycardia -nausea -vomiting -headache -seizures -arrhythmias
172
methylxanthine contraindications
-peptic ulcer disease -arrhythmias -seizure disorders
173
methylxanthine drug interactions
-major substrate of CYP3A4, 1A2, and 2E1 -increases concentration --> cimetidine, erythromycin, clarithromycin, ciprofloxacin, ticlopidine -decreases concentration --> phenobarbital, phenytoin, carbamazepine, rifampin, smoking -PDE III inhibition is a likely cause for hypotension, tachycardia, and nausea
174
omalizumab drug class
anti-IgE
175
omalizumab brand name
Xolair
176
omalizumab dosage forms
prefilled syringe and vial
177
omalizumab age groups
>= 6 years old
178
anti-IgE adverse effects
-headache -injection site reactions -arthralgias -thrombocytopenia -pharyngitis -sinusitis -upper respiratory tract infections
179
anti-IgE boxed warning
anaphylaxis
180
anti-IgE counseling tips
-do not give more than 150 mg per injection site -monitor for anaphylaxis before and after injection -FDA approved for moderate to severe persistent asthma in patients with a positive skin test or reactivity to a perennial aeroallergen and symptoms that are inadequately controlled with ICS
181
mepolizumab drug class
anti-IL5
182
mepolizumab brand name
Nucala
183
mepolizumab dosage forms
auto-injector and vial
184
mepolizumab age groups
>= 6 years old
185
mepolizumab adverse effects
-headache -injection site reactions -arthralgias -herpes zoster infection
186
mepolizumab counseling tips
-anaphylaxis (precaution) -available as in-clinic or at-home injection -monitor for anaphylaxis before and after injection -indicated for add-on maintenance treatment of patients with severe asthma with an eosinophilic phenotype
187
reslizumab drug class
anti-IL5
188
reslizumab brand name
Clinqair
189
reslizumab dosage form
liquid solution
190
reslizumab age group
>= 18 years old
191
reslizumab adverse effects
-injection site reactions -myalgias -increased creatinine phosphokinase
192
reslizumab boxed warning
anaphylaxis and malignancies
193
reslizumab counseling tips
-monitor for anaphylaxis before and after injection -indicated for add-on maintenance treatment of patients with severe asthma with an eosinophilic phenotype
194
benralizumab drug class
anti-IL5
195
benralizumab brand name
Fasenra
196
benralizumab dosage forms
auto-injector and pre-filled syringe
197
benralizumab age group
>= 12 years old
198
benralizumab adverse effects
-injection site reactions -antibody development -headache -pharyngitis -fever
199
benralizumab counseling tips
-anaphylaxis (precaution) -available in pre-filled syringe for in-office or at-home administration -indicated as an add-on maintenance treatment of severe asthma in adults and children >= 12 years of age with an eosinophilic phenotype -acts on IL-5 receptors while others act on IL-5
200
dupilumab drug class
anti-IL4/IL13
201
dupilumab brand name
Dupixent
202
dupilumab dosage form
injection
203
dupilumab age group
>= 12 years old
204
dupilumab adverse effects
-injection site reactions -antibody development -arthralgias -conjunctivitis
205
dupilumab counseling tips
-anaphylaxis (precaution) -available in pre-filled syringe for in-office or at-home administration -indicated as an add-on maintenance treatment in patients with moderate to severe asthma aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid dependent asthma
206
roflumilast drug class
phosphodiaesterase-4 inhibitors
207
roflumilast brand name
Daliresp
208
roflumilast dosage form
tablet
209
roflumilast age group
>= 12 years old
210
roflumilast indication
COPD
211
roflumilast adverse effects
hemagglutinin
212
roflumilast monitoring
liver function test and weight
213
roflumilast drug interactions
CYP3A4 (major) and CYP1A2 (minor)
214
roflumilast contraindication
Child-Pugh class B or C

PHRM825 (5 decks)

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