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Pulmonary > Asthma and COPD Pharmacology > Flashcards

Asthma and COPD Pharmacology Flashcards

1
Q

Anti-IL-5 antibody drugs

A

Mepolizumab, Reslizumab

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2
Q

Anti-IgE-antibody drugs

A

Omalizumab and Dupilumab

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3
Q

Leukotriene receptor blockers

A

Monteleukast, Zafirlukast

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4
Q

Leukotriene synthesis inhibitors

A

Zileuton

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5
Q

B2 bronchodilators

A

b2 specific, quick onset-short duration: Albuterol, Terbutaline
b2 specific, slow onset-long acting:Salmeterol, Formoterol

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6
Q

Cholinergic antagonist bronchodilators

A

Atropine, Ipratropium both no specific, Tiotropium (M3), Umeclidinium

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7
Q

How do LABAs inhibit TH1 differentiation

A

Increasing GATA3 transcription to TH2

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8
Q

B agonists adverse effects

A

Hypotension, cardiac arrhythmias, hypok QT prolongation, NV, dec paO2, agitation

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9
Q

Action of cholinergic antagonists

A

Reduce airway smooth muscle constriction
• Decrease mucus secretion
• Reduce airway remodeling (Tiotropium)
• Enhance b2-mediated bronchodilation

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10
Q

Adverse rxns of cholinergic antagonists

A 
Pupillary dilation and cycloplegia, on contact
• Constipation
• Urinary retention
• Tachycardia
• Confusion
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11
Q

Methylxanthines

A

Aminophylline and Theophylline

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12
Q

Methylxanthine actions

A 
• bronchodilation
• anti-inflammatory effect
• + inotropic & chronotropic
effects
• inc CNS activity
• inc gastric acid secretion
• weak diuretic effect
• inc skeletal muscle strength
(diaphragm)
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13
Q

Cromolyn sulfate actions

A

• Inhibits degranulation of mast cells in the lung
• May alter the activity of chloride channels
• Inhibits the inflammatory response by acting on
eosinophils
• Inhibits cough by their action on airway nerves
• Reduces bronchial hyperactivity associated with
exercise- and antigen- inhaled asthma

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14
Q

Glucocorticoid actions

A 
Decrease the production of inflammatory
cytokines and activate anti-inflammatory
genes
• Reduce mucus secretion
• Reduce bronchial hyperactivity
• Enhance the effect of b-2 adrenergic agonists
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15
Q

Glucocorticoid major adverse reaction

A

Cushing syndrome

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16
Q

Leukotriene that is a neutrophil chemoattractant

A

LTB4

17
Q

LTD4 receptor antagonists

A

Zafirlukast (Accolate)

Monteleukast (Singulair)

18
Q

Leukotriene antagonist adverse reactions

A

Z elevated liver enzymes M viral infections

19
Q

Leukotriene synthesis inhibitor

A

Zileuton

20
Q

Zileuton adverse reactions

A

Elevated hepatic enzymes (cyp1a2)

21
Q

Mepolizumab adverse reaction

A

Shingles

22
Q

Nicotine replacement drug

A

Bupropion

23
Q

Drugs contraindicated in airway disease

A
  • Sedatives
  • Beta Blockers
  • Aspirin and other Cyclooxygenase Inhibitors
24
Q

Respiratory stimulant

A

Doxapram

Pulmonary (6 decks)

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