Asthma & COPD Drugs

Question 1

what drug is a PDE4 inhibitor

Answer 1

Roflumilast

Question 2

SABA drugs

MOI?

Answer 2

Albuterol

levalbuterol

Increase CAMP in bronchial SMC ® bronchodilation

Question 3

SAMA

Answer 3

Ipratropium (Atrovent)

Bloch Ach receptors on M3 receptors in bronchial tissue ® bronchodilation

Question 4

LABA

Answer 4

Salmeterol

Formoterol

(-erol)

Question 5

LAMA

Answer 5

Aclidinium

Glycopyrrolate

Tiotropium

Umeclidinium

Question 6

SABA + SAMA

Answer 6

Combivent (albuterol-ipratropium)

Duoneb (albuterol-ipratropium)

Question 7

ICS + LAMA + LABA

Answer 7

Trelegy

(fluticasone + Umeclidinium + vilanterol)

Breztri

(budesonide + glycopyrrolate + formoterol)

Question 8

LTRA

Answer 8

• Montelukast (Singulair)
• Zafirlukast (Accolate)

Add on therapy w/ ICS

Alternative therapy for step 2 (not preferred)

Question 9

ICS

Answer 9

Beclomethasone

Budesonide - safest in pregnancy

Fluticasone propionate

Fluticasone furoate

Mometasone

Flunisolide

Ciclesonide

Question 10

LAMA in asthma

Answer 10

Tiotropium (Spiriva Respimat)

On medium dosed ICS + LABA not well controlled

Add Spiriva before move to biologics

Asthma 6+ years

Question 11

Mast cell Stabilizer

Answer 11

Cromolyn sodium (Intal)

Preventative tx prior to exercise of known allergies

Safe in pregnancy

Question 12

biologic MABs

Answer 12

• Xolair (older)
• Dupixent (newer)

Xolair - Bind to IgE to prevent binding and inhibit signaling

Dup - IL4 receptor alpha antagonist

SEVERE asthma

Question 13

ICS + LABA

Answer 13

airDuo (Respiclick)

(Fluticasone propionate + Salmeterol)

Breo Ellipta

(Fluticasone furoate + vilanterol)

Question 14

COPD ridk group initial therapy

Answer 14

Question 15

•FEV1/FVC Ratio = < _____%suggests “obstructive” (COPD)

Answer 15

<70%

Question 16

CLASSIFY AIRFLOW LIMITATION IN COPD

Answer 16

Question 17

markers of hyperinflation

Answer 17

INC in FRC

DEC IC

Question 18

define spirometry results for asthma

Answer 18

• FEV1 of > 200 mL and
• ≥12% increase from baseline measure after SABA

Question 19

how to use DPI vs MDI

Answer 19

DPI - inhale deeply and forcefully (no propellant)

MDI - inhale slowly (propellant HFA)

Question 20

sx of asthma vs COPS

Answer 20

asthma - Wheezing, breathlessness, chest tightness, coughing

COPD - Chronic sputum production, dyspnea, chronic cough

Question 21

4 ways risk groups are assessed

Answer 21

mMRC

CAT

Excerbations

Hospitalizations

Question 22

when to use ICS in COPD

Answer 22

EOS >300

hx or concurrent asthma

ICS + LABA
or

ICS + LABA + LAMA

Question 23

what drugs are reccommended for each COPD risk group

Answer 23

Question 24

mMRC > 2 IF?

Answer 24

hard time keeping up w/ someone their own age on level walking field

Question 25

COPD risk groups bases on symtpm burden and exacerbation risk

Answer 25