Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pathophysiology > Asthma Drug > Flashcards

Asthma Drug Flashcards

(41 cards)

Start Studying
1
Q

What are the short-acting beta-agonists used for asthma & COPD

A

salbutamol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the long-acting beta-agonists used for asthma & COPD?

A

Fomoterol (New drug for relive & control)

Salmeterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Name the LABA for asthma

A

Fomoterol (New drug for relive & control)

Salmeterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Name the SABA for asthma

A

salbutamol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name the drug to use in Beta 2 - emergency asthma

A

Epinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How beta agonists work?

A

They work on Gs protein receptors –> increase of AC –> increased cAMP –> bronchodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Name the SAMA ?

A

Ipratropium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Name the LAMA?

A

Tiotropium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Name the Methyxanthines drug

A

Theophylline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name the list of corticosteroids

A

Budesonide

Ciclesonide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Name the Leukotriene inhibitors

A

Montelukast

Zileuton

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is Mast cell stabilisers

A

Cromoglicic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is drug use for allergic asthma

A

Ig-E Omalizumab

(IL4 - Dupilumab) help allegic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is drug use for eosinophilic asthma

A

IL5 - Reslizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What drug will reduce B2 adrenoceptor down regulation ?

A

LABA + ICS

Below 12 , use formoterol + budesonide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What will B2 adrenoceptor agonists do?

A
  • Bronchodilation ( Airway smoothen muscle)
  • Mast cell stabilisation( used to control inflammation in asthma and to prevent exercise-induced bronchospasm
  • Increase mucociliary clearance
  • decrease microvascular leakiness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How long does SABA take to activate ?

18
Q

How long does LABA take to activate ?

19
Q

How long does Epinephrine take to activate ?

20
Q

What the adverse effect of B2 agonist/ adrenoceptor ? (SABA/LABA)

Study These Flashcards
A
  • Tremor
  • Peripheral vasodilatation
  • Palpitations & Tachycardia
  • Hyperglycaemia/ Hypokalaemia
21
Q

Ipratropium (SAMA)

Study These Flashcards
A

Mechanisms of Action:
•Inhibit M3receptor-mediated bronchoconstrictions
•Reverses vagal nerve–mediated bronchospasm & mucus secretion

Use and Efficacy

  • Use with B2 agonist + ICS +
  • Use when not tolerant of B2 agonist

Adverse Effects:

  • Limited systemic side effect
  • Dry mouth
  • Urinary retention ( esp elder)
22
Q

Theophylline

Study These Flashcards
A

Use & Efficacy

  • Lest strong than B2 agonist
  • Can use IV

Adverse Effect
•Narrow therapeutic window (therapeutic range: 5-20 mg/L)
•Many drug-drug interactions: Caution for potential drug interactions

Gastro : abdominal discomfort, anorexia, Nausea, Vomit

CNS : Nervous, tremor, anxiety, insomnia, seizures

Cardio - Arrhythmias

23
Q

Magnesium Sulphate (MgSO4)

Study These Flashcards
A

For treatment of acute asthma which can use as IV or nebulized

No Adverse effect

24
Q

List the inhaled Corticosteroids (ICS)

Study These Flashcards
A
  • Budesonide
  • Ciclesonide
  • Fluticasone (risk of adrenal suppression)
25
What does the Glucocorticoid receptor Anti inflammatory drug help asthma patient
- Reduce pro-inflammatory mediators | - Increase anti -inflammatory mediators
26
How corticosteroid help asthma?
-Reduce airway from hyper-responsiveness in 4-6weeks - Reduce frequency of acute asthma exacerbation - Prevent airway remodeling - Reduce need of B2 agonist - Reduce risk of death It does not relax airway smooth muscle Uses - For nocturnal asthma
27
What the adverse effect of corticosteroid?
- Oropharyngeal candidiasis - yeast infection develops inside your mouth - Dysphonia (disorders of the voice) - Cough / throat irritation - Adrenal suppression (e.g. fluticasone) - Easy bruising (esp in elderly ) - Cataracts - Osteoporosis
28
Leukotriene Pathway Inhibitors example
* Monetlukast-Cysteinyl-Leukotriene (CysLT) receptor antagonist * Zileuton-5-lipoxygenase (5-LOX) inhibitor
29
What the use of Leukotriene Pathway Inhibitors
Uses: It is use for chronic asthma It is use for exercise induce asthma Efficacy: - less effective than glucocorticoids - Reduce freq of asthma attack - reduce inhaled steroid - Reduce use B2 agonist - Reduce peripheral blood eosinophil levels
30
Montelukast
- Cysteinyl-Leukotriene (CysLT) Uses: - Adjunct therapy for mild to moderate asthma - Not used alone as relever to rescue asthma attach Efficacy: - Relax airways in mild asthma - Effective in aspirin sensitive asthma - Effective in exercise induces asthma
31
Cromoglicic acid Uses
Uses: Control of asthma, allergic rhinitis, vernal keratoconjunctivitis Side Effects: •Throat and nasal irritation, mouth dryness, cough •Unpleasant/Bitter taste
32
Omalizumab (Monoclonal)
- Anti bodies for allegic asthma (Anti IgE) - SC route 4 weeks Adverse effect - Risk of heart attack , ischaemic and heart block
33
Reslizumab
- eosinophilic asthma - IL5 - IV every 4 weeks Adverse Effect Oropharyngeal pain
34
Ideal combine drug for asthma
Formoterol (LABA) + Budesonide (ICS) | Salmeterol (LABA) + Fluticasone (ICS)
35
Name all bronchodilators that reverse Airway constriction
B2 Salbutamol (SABA) Relivers Formoterol (LABA) Relivers + controller Salmeterol (LABA) Controller SAMA - Ipratropium Throphylline (Methylxanthine) Leukotriene Modifiers : Montelukast (weak bronchodialators)
36
Name all Anti inflammatory that prevent recurring attack
- Corticosteriod - Budesonide , Fluticasone , Ciclesonide - Leukotriene Modifiers - Monelukast , Zileuton - Mast cell stabilisation- Cromoglicic acid - Monoclonal antibodies - Omalizumab, Reslizumab
37
What to prescribe for mild intermittent asthma/breathing issues?
SABA - Short-acting beta2-agonist
38
What to prescribe for mild persistent asthma/breathing issues?
SAB2-agonist (SABA) & low dose of ICS
39
What to prescribe for moderate persistent asthma/breathing issues?
SAB2-agonist (SABA), low dose ICS, & LABA
40
What to prescribe for severe persistent asthma/breathing issues?
SAB2-agonist (SABA), high dose ICS, & LABA
41
What to prescribe for very severe persistent asthma/breathing issues?
SAB2-agonist (SABA), high dose ICS, LABA, & OCS-Oral Corticosteroids

Pathophysiology (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions