ATLL Flashcards
1
Q
Differential diagnosis of ATLL in the blood?
A
- SS
- T-PLL
- T-LGLL
- ALCL, leukemic phase
- PTCL, leukemic phase
- T-ALL
- B- cell LPDs
- PCL
2
Q
What entity is excluded by the presence of flower cells and hypercalcemia?
A
- PTCL in leukemic phase
3
Q
What is true about CD25?
A
- inconsistently expressed in other T cell lymphomas including SS
- ATLL should have uniform and strong CD25 expression
4
Q
What is the differential diagnosis of ATLL in the lymph nodes?
A
- PTCL, NOS
- MF
- cHL
- ALCL
- AITL
- T-PLL
- T-ALL/LBL
- DLBCL
- MZL
IMP: need to do HTLV-1 testing/serology
5
Q
What is different of the R-S like cells in ATLL vs. cHL?
A
- they are both CD30+ and may be CD15+
- BUT in ATLL the RS like cells which are CD30+ usually expression other T cell markers
6
Q
What is the differential diagnosis of ATLL in the skin?
A
- MF (most common mimic with paturier micro abscesses and epidermotropism)
- Primary cutaneous ALCL
- Other T cell lymphomas
